| Full text | |
| Author(s): |
da F Costa‚ L.
;
Rodrigues‚ F.A.
;
Travieso‚ G.
Total Authors: 3
|
| Document type: | Journal article |
| Source: | Applied Physics Letters; v. 89, n. 17, p. 174101-174101, 2006. |
| Abstract | |
Protein-protein interactions can be properly modeled as scale-free complex networks, while the lethality of proteins has been correlated with the node degrees, therefore defining a lethality-centrality rule. In this work the authors revisit this relevant problem by focusing attention not on proteins as a whole, but on their functional domains, which are ultimately responsible for their binding potential. Four networks are considered: the original protein-protein interaction network, its randomized version, and two domain networks assuming different lethality hypotheses. By using formal statistical analysis, they show that the correlation between connectivity and essentiality is higher for domains than for proteins. (c) 2006 American Institute of Physics. (AU) | |
| FAPESP's process: | 99/12765-2 - Development and assessment of novel and accurate methods in shape analysis and computer vision |
| Grantee: | Luciano da Fontoura Costa |
| Support Opportunities: | Research Projects - Thematic Grants |