Impairment of Sexual Function in Rats with Epilepsy

Autor(es)

Andersen, Monica L. ^[1] ; Alvarenga, Tathiana A. ^[1] ; Scorza, Fulvio A. ^[2] ; Matos, Gabriela ^[1] ; Sonoda, Eliza Y. ^[2] ; Hirotsu, Camila ^[1] ; Cavalheiro, Esper A. ^[2] ; Tufik, Sergio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo UNIFESP, Dept Psicobiol, BR-04024002 Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Dept Neurol Expt, BR-04024002 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Sexual Medicine; v. 9, n. 9, p. 2266-2272, SEP 2012.
• Citações Web of Science: 8

Resumo

Introduction. Epilepsy is a chronic disease that affects men and women of all ages, with different levels of severity. Many individuals with epilepsy also suffer from impairments in sexual function. However, it is difficult to differentiate between the impact of the disease and the impact of antiepileptic drugs on sexual function in human subjects. Aims. To evaluate sexual behavior in adult male rats submitted to chronic pilocarpine-induced epilepsy. Methods. First, non-epileptic rats were exposed to nine training sessions to acquire sexual experience, and their baseline sexual performance was evaluated. Then, the same rats were given pilocarpine to induce status epilepticus followed by chronic epilepsy. Once the animals had developed spontaneous recurrent seizures, their sexual behavior was evaluated during three sessions. Main Outcome Measures. Examine changes in latencies to first mount, intromission, and ejaculation, and the total number of mounts, intromissions, and ejaculations. Results. All outcome measures related to sexual motivation and sexual performance were markedly impaired during chronic epilepsy compared with the baseline and the control group. Conclusion. These findings will aid in understanding the interaction between sexual behavior and epilepsy, as well as encouraging further experimental studies in human patients with epilepsy suffering from sexual dysfunction. Andersen ML, Alvarenga TA, Scorza FA, Matos G, Sonoda EY, Hirotsu C, Cavalheiro EA, and Tufik S. Impairment of sexual function in rats with epilepsy. J Sex Med 2012;9:22662272. (AU)

• Processo FAPESP: 98/14303-3 - Center for Sleep Studies
• Beneficiário: Sergio Tufik
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 11/12325-6 - Efeitos da privação de sono e da síndrome da apnéia obstrutiva do sono na função reprodutiva em homens
• Beneficiário: Tathiana Aparecida Fernandes de Alvarenga
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 09/01030-5 - Efeito da privação e restrição de sono na função reprodutiva de ratos machos
• Beneficiário: Tathiana Aparecida Fernandes de Alvarenga
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 09/14206-4 - Efeito da privação e restrição de sono na função reprodutiva de ratos machos
• Beneficiário: Monica Levy Andersen
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/50129-1 - Insuficiência renal crônica, restrição de sono e sildenafil: consequências renais, cardíacas e sexuais em um modelo animal
• Beneficiário: Camila Hirotsu
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto