Antimicrobial peptides: Clinical relevance and therapeutic implications

Autor(es)

da Silva, Fabiano Pinheiro ^[1] ; Cesar Machado, Marcel Cerqueira ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Dept Emergency Med, Lab Emergencias Med, BR-01246903 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Peptides; v. 36, n. 2, p. 308-314, AUG 2012.
• Citações Web of Science: 79

Resumo

Antimicrobial peptides (AMPS) are molecules that provide protection against environmental pathogens, acting against a large number of microorganisms, including bacteria, fungi, yeast, virus and others. Two major groups of antimicrobial peptides are found in humans: cathelicidins and defensins. Recently, several studies have furnished information that besides their role in infection diseases, antimicrobial peptides play a role in diseases as diverse as inflammatory disorders, autoimmunity and cancer. Here, we discuss the role of antimicrobial peptides and vitamin D have in such complex diseases and propose their use should be more explored in the diagnosis and treatment of such conditions. (C) 2012 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 09/17731-2 - Marcadores de infecção em pacientes críticos
• Beneficiário: Fabiano Pinheiro da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores