A general framework for multi-compartmental analysis of drug chemotherapy dynamics in human immunodeficiency virus type-1 infected individuals

Autor(es)

Joly, Marcel ^{[1, 2]} ; Pinto, Jose M. ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Chem Engn, BR-05508900 Sao Paulo - Brazil

^[2] Petrobras Petr Brasileiro SA, BR-20031915 Rio De Janeiro, RJ - Brazil

^[3] Polytech Univ, Metrotech Ctr 6, Othmer Jacobs Dept Chem & Biol Engn, Brooklyn, NY - USA

• Tipo de documento: Artigo Científico
• Fonte: Applied Mathematical Modelling; v. 36, n. 12, p. 5830-5843, DEC 2012.
• Citações Web of Science: 5

Resumo

An optimal control strategy for the highly active antiretroviral therapy associated to the acquired immunodeficiency syndrome should be designed regarding a comprehensive analysis of the drug chemotherapy behavior in the host tissues, from major viral replication sites to viral sanctuary compartments. Such approach is critical in order to efficiently explore synergistic, competitive and prohibitive relationships among drugs and, hence, therapy costs and side-effect minimization. In this paper, a novel mathematical model for HIV-1 drug chemotherapy dynamics in distinct host anatomic compartments is proposed and theoretically evaluated on fifteen conventional anti-retroviral drugs. Rather than interdependence between drug type and its concentration profile in a host tissue, simulated results suggest that such profile is importantly correlated with the host tissue under consideration. Furthermore, the drug accumulative dynamics are drastically affected by low patient compliance with pharmacotherapy, even when a single dose lacks. (C) 2012 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 99/09897-4 - Metodologias para a operação de Scheduling ótimos de sistemas reativos em batelada
• Beneficiário: Marcel Joly
• Linha de fomento: Bolsas no Brasil - Doutorado