Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A general framework for multi-compartmental analysis of drug chemotherapy dynamics in human immunodeficiency virus type-1 infected individuals

Full text
Author(s):
Joly, Marcel [1, 2] ; Pinto, Jose M. [1, 3]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Dept Chem Engn, BR-05508900 Sao Paulo - Brazil
[2] Petrobras Petr Brasileiro SA, BR-20031915 Rio De Janeiro, RJ - Brazil
[3] Polytech Univ, Metrotech Ctr 6, Othmer Jacobs Dept Chem & Biol Engn, Brooklyn, NY - USA
Total Affiliations: 3
Document type: Journal article
Source: Applied Mathematical Modelling; v. 36, n. 12, p. 5830-5843, DEC 2012.
Web of Science Citations: 5
Abstract

An optimal control strategy for the highly active antiretroviral therapy associated to the acquired immunodeficiency syndrome should be designed regarding a comprehensive analysis of the drug chemotherapy behavior in the host tissues, from major viral replication sites to viral sanctuary compartments. Such approach is critical in order to efficiently explore synergistic, competitive and prohibitive relationships among drugs and, hence, therapy costs and side-effect minimization. In this paper, a novel mathematical model for HIV-1 drug chemotherapy dynamics in distinct host anatomic compartments is proposed and theoretically evaluated on fifteen conventional anti-retroviral drugs. Rather than interdependence between drug type and its concentration profile in a host tissue, simulated results suggest that such profile is importantly correlated with the host tissue under consideration. Furthermore, the drug accumulative dynamics are drastically affected by low patient compliance with pharmacotherapy, even when a single dose lacks. (C) 2012 Elsevier Inc. All rights reserved. (AU)