Maternal exposure to picrotoxin modifies the response of the GABA(A) receptor during sexual behavior of adult male rat offspring

Autor(es)

Bernardi, Maria M. ^[1] ; Kirsten, Thiago B. ^[1] ; Teodorov, Elizabeth ^[2] ; Baso, Ana C. Z. ^[1] ; Prosdocimi, Fabio C. ^[2] ; Felicio, Luciano F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Vet Med, Dept Pathol, BR-05508270 Sao Paulo - Brazil

^[2] Fed Univ ABC, Math Comp & Cognit Ctr, Santo Andre, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Behavioural Pharmacology; v. 23, n. 7, p. 703-709, OCT 2012.
• Citações Web of Science: 1

Resumo

This study investigated whether perinatal exposure to picrotoxin, a GABA(A) antagonist, modifies the effect of muscimol, a GABA(A) agonist, on the sexual behavior of adult male rats. Two hours after birth and then once daily during the next 9 days of lactation, dams received picrotoxin (0.75 mg/kg subcutaneously) or saline (1 ml/kg subcutaneously). The adult male offspring from the picrotoxin and saline groups received saline (1 ml/kg intraperitoneally) or muscimol (1 mg/kg intraperitoneally), and 15 min later, their sexual behavior was assessed. Muscimol treatment in the saline-exposed group increased the mount and intromission latencies. However, these effects were absent in the picrotoxin-exposed groups. The latencies to first ejaculation, postejaculatory mount, and intromission were decreased in both picrotoxin-exposed groups relative to the saline-exposed groups. The picrotoxin + muscimol-treated rats required more intromissions to ejaculate and the picrotoxin-exposed groups made more ejaculations than the saline-exposed groups. Thus, muscimol treatment did not increase the mount and intromission latencies following picrotoxin exposure, but increased the ejaculation frequency, which did not differ between the picrotoxin + muscimol and the picrotoxin + saline groups. These data indicate that perinatal picrotoxin treatment interfered with GABA(A) receptor development Behavioural Pharmacology 23:703-709 (c) 2012 Wolters Kluwer Health vertical bar Lippincott Williams \& Wilkins. (AU)

• Processo FAPESP: 96/04273-4 - Avaliação da influência de fatores ambientais e químicos em parâmetros ligados à reprodução de ratos
• Beneficiário: Maria Martha Bernardi
• Modalidade de apoio: Auxílio à Pesquisa - Temático