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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Maternal exposure to picrotoxin modifies the response of the GABA(A) receptor during sexual behavior of adult male rat offspring

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Author(s):
Bernardi, Maria M. [1] ; Kirsten, Thiago B. [1] ; Teodorov, Elizabeth [2] ; Baso, Ana C. Z. [1] ; Prosdocimi, Fabio C. [2] ; Felicio, Luciano F. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sch Vet Med, Dept Pathol, BR-05508270 Sao Paulo - Brazil
[2] Fed Univ ABC, Math Comp & Cognit Ctr, Santo Andre, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Behavioural Pharmacology; v. 23, n. 7, p. 703-709, OCT 2012.
Web of Science Citations: 1
Abstract

This study investigated whether perinatal exposure to picrotoxin, a GABA(A) antagonist, modifies the effect of muscimol, a GABA(A) agonist, on the sexual behavior of adult male rats. Two hours after birth and then once daily during the next 9 days of lactation, dams received picrotoxin (0.75 mg/kg subcutaneously) or saline (1 ml/kg subcutaneously). The adult male offspring from the picrotoxin and saline groups received saline (1 ml/kg intraperitoneally) or muscimol (1 mg/kg intraperitoneally), and 15 min later, their sexual behavior was assessed. Muscimol treatment in the saline-exposed group increased the mount and intromission latencies. However, these effects were absent in the picrotoxin-exposed groups. The latencies to first ejaculation, postejaculatory mount, and intromission were decreased in both picrotoxin-exposed groups relative to the saline-exposed groups. The picrotoxin + muscimol-treated rats required more intromissions to ejaculate and the picrotoxin-exposed groups made more ejaculations than the saline-exposed groups. Thus, muscimol treatment did not increase the mount and intromission latencies following picrotoxin exposure, but increased the ejaculation frequency, which did not differ between the picrotoxin + muscimol and the picrotoxin + saline groups. These data indicate that perinatal picrotoxin treatment interfered with GABA(A) receptor development Behavioural Pharmacology 23:703-709 (c) 2012 Wolters Kluwer Health vertical bar Lippincott Williams \& Wilkins. (AU)

FAPESP's process: 96/04273-4 - Evaluation of the influence of environmental and chemical factors in parameters linked to the reproduction of mice
Grantee:Maria Martha Bernardi
Support Opportunities: Research Projects - Thematic Grants