Revisiting Langerhans cells in paracoccidioidomycosis: expression of CD207/langerin in human cutaneous and mucosal lesions

Autor(es)

Pagliari, Carla ^[1] ; Fernandes, Elaine Raniero ^[1] ; Ferreira da Silva, Wellington Luiz ^[1] ; de Lima Silva, Aline Alves ^[1] ; Stegun, Felipe Weisshaupt ^[1] ; Seixas Duarte, Maria Irma ^[1] ; Sotto, Mirian Nacagami ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Dept Patol, BR-01246903 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med, Dept Dermatol, BR-01246903 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Microbes and Infection; v. 13, n. 12-13, p. 1012-1017, NOV 2011.
• Citações Web of Science: 2

Resumo

Langerhans cells are identified by the expression of langerin. We detected this molecule in cutaneous and mucosal lesions in paracoccidioidomycosis, an important infection in Latin America. Langerin+ cells were scarcely distributed, with short dendrites in epidermis and epithelium and were frequent in the dermis and corium, in the inflammatory infiltrate and granulomas. Mucosal lesions presented a higher expression of langerin in lesions with loose granulomas. For the first time we presented the expression of langerin in paracoccidioidomycosis. Positive cells in dermis and corium could represent migrating Langerhans cells or a new subset of langerin+ cells with a role in paracoccidioidomycosis. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. (AU)

• Processo FAPESP: 08/09355-8 - Resposta imune in situ na Paracoccidioidomicose: células de perfil Th17 e células T regulatórias FOXP3 e interação do Paracoccidioides brasiliensis com elementos celulares das lesões cutâneas e mucosas
• Beneficiário: Carla Pagliari
• Modalidade de apoio: Auxílio à Pesquisa - Regular