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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Revisiting Langerhans cells in paracoccidioidomycosis: expression of CD207/langerin in human cutaneous and mucosal lesions

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Author(s):
Pagliari, Carla [1] ; Fernandes, Elaine Raniero [1] ; Ferreira da Silva, Wellington Luiz [1] ; de Lima Silva, Aline Alves [1] ; Stegun, Felipe Weisshaupt [1] ; Seixas Duarte, Maria Irma [1] ; Sotto, Mirian Nacagami [2]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Fac Med, Dept Patol, BR-01246903 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, Dept Dermatol, BR-01246903 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Microbes and Infection; v. 13, n. 12-13, p. 1012-1017, NOV 2011.
Web of Science Citations: 2
Abstract

Langerhans cells are identified by the expression of langerin. We detected this molecule in cutaneous and mucosal lesions in paracoccidioidomycosis, an important infection in Latin America. Langerin+ cells were scarcely distributed, with short dendrites in epidermis and epithelium and were frequent in the dermis and corium, in the inflammatory infiltrate and granulomas. Mucosal lesions presented a higher expression of langerin in lesions with loose granulomas. For the first time we presented the expression of langerin in paracoccidioidomycosis. Positive cells in dermis and corium could represent migrating Langerhans cells or a new subset of langerin+ cells with a role in paracoccidioidomycosis. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. (AU)

FAPESP's process: 08/09355-8 - In situ immune response in Paracoccidioidomycosis: Th17 cells and FOXp3 positive regulatory T cells and interaction of Paracoccidioides brasiliensis with cells from cutaneous and mucosal lesions
Grantee:Carla Pagliari
Support Opportunities: Regular Research Grants