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Analysis of the expression of dendritic, Langerhans and T cells in potentially malignant lesions and oral squamous cell carcinoma

Grant number: 13/18321-8
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): February 01, 2014
Effective date (End): September 30, 2016
Field of knowledge:Health Sciences - Dentistry
Principal researcher:Pablo Agustin Vargas
Grantee:Ana Carolina Amorim Pellicioli
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil


Squamous cell carcinoma is one of the most frequent malignant lesions, representing approximately 90% of cases. Many of these tumors are preceded by potentially malignant disorders such as epithelial dysplasia and proliferative verrucous leukoplakia. The immune system plays an important role in defending the body against tumor cells by recognizing and destroying malignant precursors cells. Dendritic cells are antigen presenting cells derived from bone marrow, responsible for recognize malignant cells and initiate the immune response through the activation of T cells. In the skin and mucosal tissue these cells are called Langerhans cells. In the present study the objective is to characterize the immunoprofile of CD1a, CD83, CD4 and CD8 and the protein expression of langerin/CD207 in potentially malignant disorders and oral squamous cell carcinoma, aiming a improvements in the diagnosis and prognosis of this lesions. This study will include the following groups: Mild/Moderate Epithelial Dysplasia (n = 50), Severe Dysplasia (n = 50), Proliferative Verrucous Leukoplakia (n = 15) and Oral Squamous Cell Carcinoma (n = 50). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PELLICIOLI, ANA CAROLINA AMORIM; BINGLE, LYNNE; FARTHING, PAULA; LOPES, MARCIO AJUDARTE; MARTINS, MANOELA DOMINGUES; VARGAS, PABLO AGUSTIN. Immunosurveillance profile of oral squamous cell carcinoma and oral epithelial dysplasia through dendritic and T-cell analysis. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. 46, n. 10, p. 928-933, NOV 2017. Web of Science Citations: 2.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PELLICIOLI, Ana Carolina Amorim. Expression of dendritic and T cells in potentially malignant lesions and oral squamous cell carcinoma. 2016. 81 f. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba.

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