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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Creatine Supplementation Prevents the Accumulation of Fat in the Livers of Rats Fed a High-Fat Diet

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Autor(es):
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Deminice, Rafael [1, 2] ; da Silva, Robin P. [1] ; Lamarre, Simon G. [1] ; Brown, Colin ; Furey, George N. [1] ; McCarter, Shannon A. [1] ; Jordao, Alceu Afonso [2] ; Kelly, Karen B. [3, 4] ; King-Jones, Kirst [5] ; Jacobs, Rene L. [3, 4] ; Brosnan, Margaret E. [1] ; Brosnan, John T. [1]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Mem Univ Newfoundland, Dept Biochem, St John, NF - Canada
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Lab Nutr & Metab, Sao Paulo - Brazil
[3] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB - Canada
[4] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB - Canada
[5] Univ Alberta, Dept Biol Sci, Edmonton, AB - Canada
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Journal of Nutrition; v. 141, n. 10, p. 1799-1804, OCT 2011.
Citações Web of Science: 36
Resumo

The aim of the present study was to examine the effects of creatine supplementation on liver fat accumulation induced by a high-fat diet in rats. Rats were fed 1 of 3 different diets for 3 wk: a control liquid diet (C), a high-fat liquid diet (HF), or a high-fat liquid diet supplemented with creatine (HFC). The C and HF diets contained, respectively, 35 and 71% of energy derived from fat. Creatine supplementation involved the addition of 1% (wt:v) of creatine monohydrate to the liquid diet. The HF diet increased total liver fat concentration, liver TG, and liver TBARS and decreased the hepatic S-adenosylmethionine (SAM) concentration. Creatine supplementation normalized all of these perturbations. Creatine supplementation significantly decreased the renal activity of L-arginine:glycine amidinotransferase and plasma guanidinoacetate and prevented the decrease in hepatic SAM concentration in rats fed the HF diet. However, there was no change in either the phosphatidylcholine:phosphatidylethanolamine (PE) ratio or PE N-methyltransferase activity. The HF diet decreased mRNA for PPAR as well as 2 of its targets, carnitine palmitoyltransferase and long-chain acylCoA dehydrogenase. Creatine supplementation normalized these mRNA levels. In conclusion, creatine supplementation prevented the fatty liver induced by feeding rats a HF diet, probably by normalization of the expression of key genes of beta-oxidation. J. Nutr. 141: 1799-1804, 2011. (AU)

Processo FAPESP: 07/08099-5 - Efeitos da suplementação de creatina sobre homocisteína e estresse oxidativo após exercício agudo aeróbio e anaeróbio em ratos
Beneficiário:Rafael Deminice
Linha de fomento: Bolsas no Brasil - Doutorado