Clinicopathological factors are predictors of distant metastasis from major salivary gland carcinomas

Autor(es)

Mariano, F. V. ^[1] ; da Silva, S. D. ^[2] ; Chulan, T. C. ^[2] ; de Almeida, O. P. ^[1] ; Kowalski, L. P. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Dept Oral Diag, Sch Dent Piracicaba, BR-13414018 Sao Paulo - Brazil

^[2] AC Camargo Hosp, Dept Head & Neck Surg & Otorhinolaryngol, BR-01509900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Oral and Maxillofacial Surgery; v. 40, n. 5, p. 504-509, MAY 2011.
• Citações Web of Science: 30

Resumo

The risk of distant metastasis of salivary gland cancers has usually been associated with histological type, tumour size, and site. The aim of this study was to evaluate a series of patients with major salivary gland carcinomas in order to identify potential risk factors associated with distant metastasis. 255 patients treated for major salivary gland carcinoma in Brazil from 1953 to 2004 were reviewed. Clinical and treatment data were obtained from the medical records and histological features reviewed. 57 (22%) of 255 patients had distant metastasis. The lungs were the most common metastatic site (40 cases, 65%) and adenoid cystic carcinoma the most frequent histological type involved (27 cases, 47%). The percentage of tumours in the submandibular, parotid, and sublingual glands that presented distant metastasis was 42%, 20%, and 17%, respectively. These results provide evidences that clinicopathological factors (tumour site and histology) are significant predictors of distant metastasis in patients with major salivary gland carcinomas. (AU)

• Processo FAPESP: 06/61039-8 - Identificacao de marcadores moleculares de progressao e prognostico em carcinomas epidermoides de boca.
• Beneficiário: Luiz Paulo Kowalski
• Modalidade de apoio: Auxílio à Pesquisa - Regular