Simvastatin-induced cardiac autonomic control improvement in fructose-fed female rats

Autor(es)

da Silva, Renata Juliana ^{[1, 2]} ; Bernardes, Nathalia ^{[1, 3]} ; Brito, Janaina de O. ^[3] ; Sanches, Iris Callado ^{[3, 4]} ; Irigoyen, Maria Claudia ^[4] ; De Angelis, Katia ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Anat, Lab Chem Neuroanat, BR-05508 Sao Paulo - Brazil

^[3] Nove de Julho Univ, Lab Translat Physiol, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Fac Med, Inst Heart, Hypertens Unit, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinics; v. 66, n. 10, p. 1793-1796, 2011.
• Citações Web of Science: 13

Resumo

OBJECTIVE: Because autonomic dysfunction has been found to lead to cardiometabolic disorders and because studies have reported that simvastatin treatment has neuroprotective effects, the objective of the present study was to investigate the effects of simvastatin treatment on cardiovascular and autonomic changes in fructose-fed female rats. METHODS: Female Wistar rats were divided into three groups: controls (n=8), fructose (n=8), and fructose+ simvastatin (n=8). Fructose overload was induced by supplementing the drinking water with fructose (100 mg/L, 18 wks). Simvastatin treatment (5 mg/kg/day for 2 wks) was performed by gavage. The arterial pressure was recorded using a data acquisition system. Autonomic control was evaluated by pharmacological blockade. RESULTS: Fructose overload induced an increase in the fasting blood glucose and triglyceride levels and insulin resistance. The constant rate of glucose disappearance during the insulin intolerance test was reduced in the fructose group (3.4+ 0.32%/min) relative to that in the control group (4.4+ 0.29%/min). Fructose+simvastatin rats exhibited increased insulin sensitivity (5.4+0.66%/min). The fructose and fructose+simvastatin groups demonstrated an increase in the mean arterial pressure compared with controls rats (fructose: 124+2 mmHg and fructose+simvastatin: 126 + 3 mmHg vs. controls: 112 + 2 mmHg). The sympathetic effect was enhanced in the fructose group (73 + 7 bpm) compared with that in the control (48 + 7 bpm) and fructose+simvastatin groups (31+8 bpm). The vagal effect was increased in fructose+simvastatin animals (84 + 7 bpm) compared with that in control (49 + 9 bpm) and fructose animals (46+5 bpm). CONCLUSION: Simvastatin treatment improved insulin sensitivity and cardiac autonomic control in an experimental model of metabolic syndrome in female rats. These effects were independent of the improvements in the classical plasma lipid profile and of reductions in arterial pressure. These results support the hypothesis that statins reduce the cardiometabolic risk in females with metabolic syndrome. (AU)

• Processo FAPESP: 05/60828-6 - Efeitos cardiovasculares e matabólicos do tratamento com sinvastatina e do treinamento físico em modelo experimental de menopausa
• Beneficiário: Nathalia Bernardes
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 11/11267-2 - Simvastatin induced cardiac autonomic control improvement in fructose fed female rats
• Beneficiário: Kátia de Angelis Lobo D Avila
• Modalidade de apoio: Auxílio à Pesquisa - Publicações científicas - Artigo
• Processo FAPESP: 07/57595-5 - Efeitos do treinamento físico no controle autônomo cardiovascular em fêmeas saudáveis e submetidas à privação dos hormônios ovarianos: papel do estresse oxidativo
• Beneficiário: Kátia de Angelis Lobo D Avila
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 05/60827-0 - Efeitos do treinamento fisico no perfil hemodinamico e metabolico em um modelo experimental de sindrome metabolica.
• Beneficiário: Janaina de Oliveira Brito
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica