Lower numbers of circulating natural killer T (NK T) cells in individuals with human T lymphotropic virus type 1 (HTLV-1) associated neurological disease

Autor(es):Mostrar menos -

Ndhlovu, L. C. ^[1] ; Snyder-Cappione, J. E. ^[1] ; Carvalho, K. I. ^[2] ; Leal, F. E. ^[2] ; Loo, C. P. ^[1] ; Bruno, F. R. ^[2] ; Jha, A. R. ^[1] ; Devita, D. ; Hasenkrug, A. M. ^[1] ; Barbosa, H. M. R. ^[3] ; Segurado, A. C. ^[4] ; Nixon, D. F. ^[1] ; Murphy, E. L. ^{[5, 6]} ; Kallas, E. G. ^{[2, 3]}

Afiliação do(s) autor(es)

^[1] Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA 94110 - USA

^[2] Univ Sao Paulo, Sch Med, Div Clin Immunol & Allergy, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Div Infect Dis, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Sch Med, Dept Infect Dis, Sao Paulo - Brazil

^[5] Blood Syst Res Inst, San Francisco, CA - USA

^[6] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94110 - USA

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL AND EXPERIMENTAL IMMUNOLOGY; v. 158, n. 3, p. 294-299, DEC 2009.
• Citações Web of Science: 10

Resumo

Human T lymphotropic virus type 1 (HTLV-1) infects 10-20 million people worldwide. The majority of infected individuals are asymptomatic; however, approximately 3% develop the debilitating neurological disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). There is also currently no cure, vaccine or effective therapy for HTLV-1 infection, and the mechanisms for progression to HAM/TSP remain unclear. NK T cells are an immunoregulatory T cell subset whose frequencies and effector functions are associated critically with immunity against infectious diseases. We hypothesized that NK T cells are associated with HAM/TSP progression. We measured NK T cell frequencies and absolute numbers in individuals with HAM/TSP infection from two cohorts on two continents: Sao Paulo, Brazil and San Francisco, CA, USA, and found significantly lower levels when compared with healthy subjects and/or asymptomatic carriers. Also, the circulating NK T cell compartment in HAM/TSP subjects is comprised of significantly more CD4(+) and fewer CD8(+) cells than healthy controls. These findings suggest that lower numbers of circulating NK T cells and enrichment of the CD4(+) NK T subset are associated with HTLV-1 disease progression. (AU)

• Processo FAPESP: 04/15856-9 - Análise prospectiva das características virológicas e imunológicas em indivíduos com infecção recente pelo HIV-1 das cidades de São Paulo e Santos, SP
• Beneficiário: Ricardo Sobhie Diaz
• Modalidade de apoio: Auxílio à Pesquisa - Temático