Altered Ex Vivo Expression of Caspase 8, Caspase 9, and Bcl-2 Is Associated with T-Cell Hyporeactivity in Patients with Paracoccidioidomycosis

Autor(es)

Cacere, Camila R. ^[1] ; Mendes-Giannini, Maria J. S. ^[2] ; do Valle, Antonio Carlos F. ^[3] ; Duarte, Alberto J. S. ^[1] ; Benard, Gil ^{[1, 4]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Lab Dermatol & Immunodeficiencies, BR-05403903 Sao Paulo - Brazil

^[2] Sao Paulo State Univ, Fac Pharmaceut Sci, Dept Clin Pathol, Sao Paulo - Brazil

^[3] Fiocruz MS, Inst Pesquisa Evandro Chagas, BR-21045900 Rio De Janeiro - Brazil

^[4] Univ Sao Paulo, Sch Med, Clin Hosp, Div Infect Dis, Syst Mycoses Outpatient Unit, BR-05403903 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinical and Vaccine Immunology; v. 16, n. 6, p. 953-955, JUN 2009.
• Citações Web of Science: 2

Resumo

To better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells would in vivo be driven to a tolerant state and apoptosis. (AU)

• Processo FAPESP: 02/10893-8 - Aspectos moleculares envolvidos na apoptose de celulas mononucleares de pacientes com paracoccidioidomicose.
• Beneficiário: Camila Rodrigues Cacere
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 02/07306-3 - Eventos de sinalização na interação de Paracoccidioides brasiliensis com células epiteliais e células mononucleares envolvidas na resposta imune
• Beneficiário: Maria José Soares Mendes Giannini
• Modalidade de apoio: Auxílio à Pesquisa - Temático