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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Altered Ex Vivo Expression of Caspase 8, Caspase 9, and Bcl-2 Is Associated with T-Cell Hyporeactivity in Patients with Paracoccidioidomycosis

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Author(s):
Cacere, Camila R. [1] ; Mendes-Giannini, Maria J. S. [2] ; do Valle, Antonio Carlos F. [3] ; Duarte, Alberto J. S. [1] ; Benard, Gil [1, 4]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Sch Med, Lab Dermatol & Immunodeficiencies, BR-05403903 Sao Paulo - Brazil
[2] Sao Paulo State Univ, Fac Pharmaceut Sci, Dept Clin Pathol, Sao Paulo - Brazil
[3] Fiocruz MS, Inst Pesquisa Evandro Chagas, BR-21045900 Rio De Janeiro - Brazil
[4] Univ Sao Paulo, Sch Med, Clin Hosp, Div Infect Dis, Syst Mycoses Outpatient Unit, BR-05403903 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Clinical and Vaccine Immunology; v. 16, n. 6, p. 953-955, JUN 2009.
Web of Science Citations: 2
Abstract

To better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells would in vivo be driven to a tolerant state and apoptosis. (AU)

FAPESP's process: 02/07306-3 - Signaling events in the interaction of Paracoccidioides brasiliensis with epithelial and mononuclear cells involved in immune response
Grantee:Maria José Soares Mendes Giannini
Support Opportunities: Research Projects - Thematic Grants