From immune response to cancer: a spot on the low molecular weight protein tyrosine phosphatase

Autor(es)

Souza, A. C. S. ^[1] ; Azoubel, S. ^[1] ; Queiroz, K. C. S. ^[2] ; Peppelenbosch, M. P. ^[2] ; Ferreira, C. V. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Biochem, Inst Biol, Dept Bioquim, BR-13083970 Campinas, SP - Brazil

^[2] Univ Groningen, Univ Med Ctr Groningen, Dept Cell Biol, Groningen - Netherlands

• Tipo de documento: Artigo de Revisão
• Fonte: CELLULAR AND MOLECULAR LIFE SCIENCES; v. 66, n. 7, p. 1140-1153, APR 2009.
• Citações Web of Science: 41

Resumo

Reversible tyrosine phosphorylation is a key posttranslational regulatory modification of proteins in all eukaryotic cells in normal and pathological processes. Recently a pivotal janus-faced biological role of the low molecular weight protein tyrosine phosphatase (LMWPTP) has become clear. On the one hand this enzyme is important in facilitating appropriate immune responses towards infectious agents, on the other hand it mediates exaggerated inflammatory responses toward innocuous stimuli. The evidence that LMWPTP plays a role in oncological processes has added a promising novel angle. In this review we shall focus on the regulation of LMWPTP enzymatic activity of signaling pathways of different immunological cells, the relation between genetic polymorphism of LMWPTP and predisposition to some type of inflammatory disorders and the contribution of this enzyme to cancer cell onset, growth and migration. Therefore, the LMWPTP is an interesting target for pharmacological intervention, thus modifying both inappropriate cellular immune responses and cancer cell aggressiveness. (AU)

• Processo FAPESP: 06/06399-9 - Proteínas tirosina fosfatases como alvos estratégicos para a reversão da resistência de células tumorais
• Beneficiário: Ana Carolina Santos de Souza Galvão
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 07/59179-9 - Modulação química da proteína tirosina fosfatase como estratégia para a reversão da resistência de células tumorais
• Beneficiário: Carmen Veríssima Ferreira
• Modalidade de apoio: Bolsas no Exterior - Pesquisa