Enhancement of diagnostic efficiency by a gamma interferon release assay for pulmonary tuberculosis

Autor(es)

Kanunfre, Kelly Aparecida ^[1] ; Munhoz Leite, Olavo Henrique ^[2] ; Lopes, Max Igor ^[2] ; Litvoc, Marcelo ^[2] ; Ferreira, Antonio Walter ^{[3, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Trop Med, Lab Soroepidemiol & Imunobiol, BR-05403000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Hosp Clin, Clin Infect Dis, BR-05403000 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Dept Infect & Parasit Dis, BR-05403000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinical and Vaccine Immunology; v. 15, n. 6, p. 1028-1030, JUN 2008.
• Citações Web of Science: 14

Resumo

This study was designed to examine the use of the QuantiFERON-TB Gold assay as an aid in the diagnosis of active pulmonary tuberculosis (TB) in Brazilian patients. Using the receiver operating characteristic curve, the cutoff was adjusted to >= 0.20 IU/ml. The sensitivity increased to 86%, with 100% specificity. All TB patients with negative sputum smear microscopy and negative culture results were positive using this test. (AU)

• Processo FAPESP: 03/08308-2 - Padronizacao e desenvolvimento de testes sorologicos para o diagnostico da tuberculose humana.
• Beneficiário: Antonio Walter Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Regular