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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Enhancement of diagnostic efficiency by a gamma interferon release assay for pulmonary tuberculosis

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Author(s):
Kanunfre, Kelly Aparecida [1] ; Munhoz Leite, Olavo Henrique [2] ; Lopes, Max Igor [2] ; Litvoc, Marcelo [2] ; Ferreira, Antonio Walter [3, 1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Inst Trop Med, Lab Soroepidemiol & Imunobiol, BR-05403000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Hosp Clin, Clin Infect Dis, BR-05403000 Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Dept Infect & Parasit Dis, BR-05403000 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Clinical and Vaccine Immunology; v. 15, n. 6, p. 1028-1030, JUN 2008.
Web of Science Citations: 14
Abstract

This study was designed to examine the use of the QuantiFERON-TB Gold assay as an aid in the diagnosis of active pulmonary tuberculosis (TB) in Brazilian patients. Using the receiver operating characteristic curve, the cutoff was adjusted to >= 0.20 IU/ml. The sensitivity increased to 86%, with 100% specificity. All TB patients with negative sputum smear microscopy and negative culture results were positive using this test. (AU)