Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil

Autor(es)

Funari, Cristiano Soleo ^[1] ; Gullo, Fernanda Patricia ^[2] ; Napolitano, Assunta ^[3] ; Carneiro, Renato Lajarim ^[4] ; Soares Mendes-Giannini, Maria Jose ^[2] ; Fusco-Almeida, Ana Marisa ^[2] ; Piacente, Sonia ^[3] ; Pizza, Cosimo ^[3] ; Siqueira Silva, Dulce Helena ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, Inst Chem, NuBBE, BR-14801970 Araraquara, SP - Brazil

^[2] Sao Paulo State Univ, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP - Brazil

^[3] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Fisciano, SA - Italy

^[4] Univ Fed Sao Carlos, Dept Chem, BR-13565905 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Food Chemistry; v. 135, n. 3, p. 2086-2094, DEC 1 2012.
• Citações Web of Science: 22

Resumo

The Lippia genus is used in ethnobotany as food, beverages, seasoning and antiseptic remedies, among others. The chemical compositions of fifteen extracts of six Lippia species were investigated comparatively by HPLC-PDA. To avoid data replication of previous works on this genus, Lippia lupulina Cham. root ethanol extract was selected for isolation procedures based on Principal Component Analyses (PCA) of such data. Seven compounds previously unreported in this genus were isolated from this extract (a triterpene, two furanonaphtoquinones, a furanochromone, an isoflavone, a stilbene and an iridoid). The activities of extracts, fractions and pure compounds towards Candida albicans, Candida krusei, Candida parapsilosis and Cryptococcus neoformans were investigated. Two fractions from the extract of Lippia salviaefolia leaves showed marked inhibition of fungal growth, in addition to verbascoside and asebogenin, which showed MICs lower than 15.6 mu g/ml and may be promising leads for the development of new antifungal agents, especially against C. neoformans. (C) 2012 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 04/07932-7 - Busca de compostos naturais antitumorais, antioxidantes, antiinflamatórios, antidiabéticos, inibidores de acetilcolinesterase e mieloperoxidase no Cerrado e na Mata Atlântica
• Beneficiário: Dulce Helena Siqueira Silva
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático