| Texto completo | |
| Autor(es): Mostrar menos - |
Rodrigues, Bruno
[1, 2]
;
Jorge, Luciana
[1]
;
Mostarda, Cristiano T.
[1]
;
Rosa, Kaleizu T.
[1]
;
Medeiros, Alessandra
[3]
;
Malfitano, Christiane
[1]
;
de Souza, Jr., Alcione L.
[4]
;
da Silva Viegas, Katia Apareceda
[4]
;
Lacchini, Silvia
[4]
;
Curi, Rui
[4]
;
Brum, Patricia C.
[5]
;
De Angelis, Katia
[6]
;
Irigoyen, Maria Claudia
[1]
Número total de Autores: 13
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Hypertens Unit, Heart Inst InCor, Sch Med, BR-05403000 Sao Paulo - Brazil
[2] Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Biosci, Santos, SP - Brazil
[4] Univ Sao Paulo, Inst Biomed Sci, BR-05403000 Sao Paulo - Brazil
[5] Univ Sao Paulo, Sch Phys Educ & Sports, BR-05403000 Sao Paulo - Brazil
[6] Nove Julho Univ, Sao Paulo - Brazil
Número total de Afiliações: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF CARDIAC FAILURE; v. 18, n. 9, p. 734-744, SEP 2012. |
| Citações Web of Science: | 20 |
| Resumo | |
Background: Exercise training (ET) has been used as a nonpharmacological strategy for treatment of diabetes and myocardial infarction (MI) separately. We evaluated the effects ET on functional and molecular left ventricular (LV) parameters as well as on autonomic function and mortality in diabetics after MI. Methods and Results: Male Wistar rats were divided into control (C), sedentary-diabetic infarcted (SDI), and trained-diabetic infarcted (TDI) groups. MI was induced after 15 days of streptozotocin-diabetes induction. Seven days after MI, the trained group underwent ET protocol (90 days, 50-70% maximal oxygen consumption-VO(2)max). LV function was evaluated noninvasively and invasively; baroreflex sensitivity, pulse interval variability, cardiac output, tissue blood flows, VEGF mRNA and protein, HIF1-alpha mRNA, and Ca2+ handling proteins were measured. MI area was reduced in TDI (21 +/- 4%) compared with SDI (38 +/- 4%). ET induced improvement in cardiac function, hemodynamics, and tissue blood flows. These changes were probable consequences of a better expression of Ca2+ handling proteins, increased VEGF mRNA and protein expression as well as improvement in autonomic function, that resulted in reduction of mortality in TDI (33%) compared with SDI (68%) animals. Conclusions: ET reduced cardiac and peripheral dysfunction and preserved autonomic control in diabetic infarcted rats. Consequently, these changes resulted in improved VO(2)max and survival after MI. (J Cardiac Fail 2012; 18:734-744) (AU) | |
| Processo FAPESP: | 07/58942-0 - Da bancada à clínica: desenvolvimento de biomarcadores como preditores da resposta à terapêutica e lesão de órgãos-alvo na hipertensão arterial sistemática |
| Beneficiário: | Eduardo Moacyr Krieger |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 06/53800-0 - Papel do treinamento fisico na mortalidade de ratos diabeticos pos infarto do miocardio: avaliacoes das funcoes cardiacas. |
| Beneficiário: | Luciana Jorge |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |