Aerobic Exercise Training Delays Cardiac Dysfunction and Improves Autonomic Control of Circulation in Diabetic Rats Undergoing Myocardial Infarction

Author(s):Show less -

Rodrigues, Bruno ^{[1, 2]} ; Jorge, Luciana ^[1] ; Mostarda, Cristiano T. ^[1] ; Rosa, Kaleizu T. ^[1] ; Medeiros, Alessandra ^[3] ; Malfitano, Christiane ^[1] ; de Souza, Jr., Alcione L. ^[4] ; da Silva Viegas, Katia Apareceda ^[4] ; Lacchini, Silvia ^[4] ; Curi, Rui ^[4] ; Brum, Patricia C. ^[5] ; De Angelis, Katia ^[6] ; Irigoyen, Maria Claudia ^[1]

Affiliation

^[1] Univ Sao Paulo, Hypertens Unit, Heart Inst InCor, Sch Med, BR-05403000 Sao Paulo - Brazil

^[2] Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Biosci, Santos, SP - Brazil

^[4] Univ Sao Paulo, Inst Biomed Sci, BR-05403000 Sao Paulo - Brazil

^[5] Univ Sao Paulo, Sch Phys Educ & Sports, BR-05403000 Sao Paulo - Brazil

^[6] Nove Julho Univ, Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF CARDIAC FAILURE; v. 18, n. 9, p. 734-744, SEP 2012.
• Web of Science Citations: 20

Abstract

Background: Exercise training (ET) has been used as a nonpharmacological strategy for treatment of diabetes and myocardial infarction (MI) separately. We evaluated the effects ET on functional and molecular left ventricular (LV) parameters as well as on autonomic function and mortality in diabetics after MI. Methods and Results: Male Wistar rats were divided into control (C), sedentary-diabetic infarcted (SDI), and trained-diabetic infarcted (TDI) groups. MI was induced after 15 days of streptozotocin-diabetes induction. Seven days after MI, the trained group underwent ET protocol (90 days, 50-70% maximal oxygen consumption-VO(2)max). LV function was evaluated noninvasively and invasively; baroreflex sensitivity, pulse interval variability, cardiac output, tissue blood flows, VEGF mRNA and protein, HIF1-alpha mRNA, and Ca2+ handling proteins were measured. MI area was reduced in TDI (21 +/- 4%) compared with SDI (38 +/- 4%). ET induced improvement in cardiac function, hemodynamics, and tissue blood flows. These changes were probable consequences of a better expression of Ca2+ handling proteins, increased VEGF mRNA and protein expression as well as improvement in autonomic function, that resulted in reduction of mortality in TDI (33%) compared with SDI (68%) animals. Conclusions: ET reduced cardiac and peripheral dysfunction and preserved autonomic control in diabetic infarcted rats. Consequently, these changes resulted in improved VO(2)max and survival after MI. (J Cardiac Fail 2012; 18:734-744) (AU)

• FAPESP's process: 07/58942-0 - From the bench to clinical trials: development of biomarkers as response predictors to therapy and target organs damage in systemic arterial hypertension
• Grantee: Eduardo Moacyr Krieger
• Support Opportunities: Research Projects - Thematic Grants