Chronic caffeine intake increases androgenic stimuli, epithelial cell proliferation and hyperplasia in rat ventral prostate

Autor(es)

Sarobo, Carolina ^[1] ; Lacorte, Livia M. ^[1] ; Martins, Marcela ^[1] ; Rinaldi, Jaqueline C. ^[1] ; Moroz, Andrei ^[1] ; Scarano, Wellerson R. ^[1] ; Delella, Flavia K. ^[1] ; Felisbino, Sergio L. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista UNESP, Dept Morfol, Inst Biociencias, BR-18618970 Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Experimental Pathology; v. 93, n. 6, p. 429-437, DEC 2012.
• Citações Web of Science: 14

Resumo

Coffee intake has been associated with a low risk of developing cancer, including prostate cancer, which is one of the most commonly diagnosed cancer in men. However, few studies have evaluated the chronic effects of caffeine, which is the most abundant methylxanthine in coffee, on prostate morphology and physiology. In the present study, we investigated the effects of chronic, low-dose caffeine intake on rat prostate morphology from puberty to adulthood. Five-week-old male Wistar rats were randomized into two experimental groups: caffeine-treated (20 ppm in drinking water, n = 12) and control (n = 12). The ventral and dorsolateral prostates were dissected, weighted and submitted to morphological, morphometrical and immunohistochemical analysis of cellular proliferation, apoptosis and androgen receptor (AR) tissue expression. The testosterone (T) and dihydrotestosterone (DHT) concentrations were measured in the plasma. Our results show that caffeine intake increased the concentrations of T and DHT, organ weight, epithelial cell proliferation and AR tissue expression in the ventral prostatic lobe. All the ventral prostates from the caffeine-treated animals presented various degrees of epithelial and stromal hyperplasia. Our results suggest that chronic caffeine intake from puberty increases androgenic signalling and cell proliferation in the rat prostate gland and can be related to the development of benign prostatic hyperplasia. (AU)

• Processo FAPESP: 09/50850-5 - Exposição crônica ao cádmio e/ou à cafeína: alterações estruturais, ultra-estruturais e bioquímicas na próstata do rato
• Beneficiário: Lívia Maria Lacorte
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 09/52747-7 - Alterações morfofuncionais na próstata do rato Wistar: programação fetal por restrição protéica in útero e exposição crônica ao cádmio e a cafeína na puberdade
• Beneficiário: Sérgio Luis Felisbino
• Modalidade de apoio: Auxílio à Pesquisa - Regular