| Texto completo | |
| Autor(es): |
Alvarado-Mora, Monica V.
[1, 2]
;
Romano, Camila M.
[3]
;
Gomes-Gouvea, Michele S.
[1, 2]
;
Gutierrez, Maria F.
[4]
;
Carrilho, Flair J.
[1, 2]
;
Pinho, Joao R. R.
[1, 2]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Sch Med, Dept Gastroenterol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Sao Paulo Inst Trop Med, Lab Gastroenterol & Hepatol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Sao Paulo Inst Trop Med, Dept Infect & Parasit Dis LIMHC, Sao Paulo - Brazil
[4] Pontificia Javeriana Univ, Dept Microbiol, Virol Lab, Bogota - Colombia
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | VIROLOGY JOURNAL; v. 9, OCT 24 2012. |
| Citações Web of Science: | 9 |
| Resumo | |
Background: Hepatitis B virus (HBV) infection is one of the most prevalent viral infections in humans and represents a serious public health problem. In Colombia, our group reported recently the presence of subgenotypes F3, A2 and genotype G in Bogota. The aim of this study was to characterize the HBV genotypes circulating in Quibdo, the largest Afro-descendant community in Colombia. Sixty HBsAg-positive samples were studied. A fragment of 1306 bp (S/POL) was amplified by nested PCR. Positive samples to S/POL fragment were submitted to PCR amplification of the HBV complete genome. Findings: The distribution of HBV genotypes was: A1 (52.17%), E (39.13%), D3 (4.3%) and F3/A1 (4.3%). An HBV recombinant strain subgenotype F3/A1 was found for the first time. Conclusions: This study is the first analysis of complete HBV genome sequences from Afro-Colombian population. It was found an important presence of HBV/A1 and HBV/E genotypes. A new recombinant strain of HBV genotype F3/A1 was reported in this population. This fact may be correlated with the introduction of these genotypes in the times of slavery. (AU) | |
| Processo FAPESP: | 08/50461-6 - Estudo da variabilidade genotípica dos vírus da Hepatite B e Hepatite C na Colômbia |
| Beneficiário: | Monica Viviana Alvarado Mora |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 11/50562-0 - Caracterização das mutações associadas a evolução do carcinoma hepatocelular (CHC) em pacientes infectados pelo vírus da hepatite B e da hepatite C |
| Beneficiário: | João Renato Rebello Pinho |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 07/53457-7 - Estudo da variabilidade genotípica dos vírus das Hepatites B e C na Colômbia |
| Beneficiário: | João Renato Rebello Pinho |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |