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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Phylogenetic analysis of complete genome sequences of hepatitis B virus from an Afro-Colombian community: presence of HBV F3/A1 recombinant strain

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Author(s):
Alvarado-Mora, Monica V. [1, 2] ; Romano, Camila M. [3] ; Gomes-Gouvea, Michele S. [1, 2] ; Gutierrez, Maria F. [4] ; Carrilho, Flair J. [1, 2] ; Pinho, Joao R. R. [1, 2]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sch Med, Dept Gastroenterol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Sao Paulo Inst Trop Med, Lab Gastroenterol & Hepatol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Sao Paulo Inst Trop Med, Dept Infect & Parasit Dis LIMHC, Sao Paulo - Brazil
[4] Pontificia Javeriana Univ, Dept Microbiol, Virol Lab, Bogota - Colombia
Total Affiliations: 4
Document type: Journal article
Source: VIROLOGY JOURNAL; v. 9, OCT 24 2012.
Web of Science Citations: 9
Abstract

Background: Hepatitis B virus (HBV) infection is one of the most prevalent viral infections in humans and represents a serious public health problem. In Colombia, our group reported recently the presence of subgenotypes F3, A2 and genotype G in Bogota. The aim of this study was to characterize the HBV genotypes circulating in Quibdo, the largest Afro-descendant community in Colombia. Sixty HBsAg-positive samples were studied. A fragment of 1306 bp (S/POL) was amplified by nested PCR. Positive samples to S/POL fragment were submitted to PCR amplification of the HBV complete genome. Findings: The distribution of HBV genotypes was: A1 (52.17%), E (39.13%), D3 (4.3%) and F3/A1 (4.3%). An HBV recombinant strain subgenotype F3/A1 was found for the first time. Conclusions: This study is the first analysis of complete HBV genome sequences from Afro-Colombian population. It was found an important presence of HBV/A1 and HBV/E genotypes. A new recombinant strain of HBV genotype F3/A1 was reported in this population. This fact may be correlated with the introduction of these genotypes in the times of slavery. (AU)