Biosynthesis of two dihydropyrrole-polyketides from a marine-derived Penicillium citrinum

Autor(es)

Romminger, Stelamar ^[1] ; Pimenta, Eli F. ^[1] ; Nascimento, Eduardo S. ^[2] ; Ferreira, Antonio G. ^[2] ; Berlinck, Roberto G. S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 23, n. 10, p. 1783-1788, OCT 2012.
• Citações Web of Science: 7

Resumo

Feeding experiments with 13C-labeled precursors were performed in order to establish the biosynthesis of two N-acylated dihydropyrroles, (8E)-1-(2,3-dihydro-1H-pyrrol-1-yl)-2-methyldec8-ene-1,3-dione (1) and 1-(2,3-dihydro-1H-pyrrol-1-yl)-2-methyldecane-1,3-dione (2), isolated from the cultures of a marine-derived Penicillium citrinum. The biosynthesis of both, 1 and 2, involves the incorporation of acetate, methionine and ornithine. (AU)

• Processo FAPESP: 10/05100-5 - Investigação de rotas biossintéticas de policetídeos e alcaloides de microrganismos marinhos
• Beneficiário: Eli Fernando Pimenta
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 09/51199-6 - Investigacao de rotas biossinteticas de produtos naturais marinhos. ii. metabolitos secundarios de fungos marinhos do genero penicillium
• Beneficiário: Roberto Gomes de Souza Berlinck
• Modalidade de apoio: Auxílio à Pesquisa - Regular