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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biosynthesis of Two Dihydropyrrole-Polyketides from a Marine-Derived Penicillium citrinum

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Romminger, Stelamar [1] ; Pimenta, Eli F. [1] ; Nascimento, Eduardo S. [2] ; Ferreira, Antonio G. [2] ; Berlinck, Roberto G. S. [1]
Total Authors: 5
[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 23, n. 10, p. 1783-1788, OCT 2012.
Web of Science Citations: 7

Feeding experiments with C-13-labeled precursors were performed in order to establish the biosynthesis of two N-acylated dihydropyrroles, (8E)-1-(2,3-dihydro-1H-pyrrol-1-yl)-2- methyldec-8-ene-1,3-dione (1) and 1-(2,3-dihydro-1H-pyrrol-1-yl)-2- methyldecane-1,3-dione (2), isolated from the cultures of a marine-derived Penicillium citrinum. The biosynthesis of both, 1 and 2, involves the incorporation of acetate, methionine and ornithine. (AU)

FAPESP's process: 10/05100-5 - Investigation of biosynthetic routes of polyketides and alkaloids from marine microorganisms
Grantee:Eli Fernando Pimenta
Support type: Scholarships in Brazil - Post-Doctorate