Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations

Autor(es)

Seiva, Fabio R. F. ^[1] ; Chuffa, Luiz Gustavo A. ^[2] ; Braga, Camila Pereira ^[1] ; Amorim, Joao Paulo A. ^[3] ; Fernandes, Ana Angelica H. ^[1]

Afiliação do(s) autor(es)

^[1] UNESP Univ State Sao Paulo, Dept Chem & Biochem, Inst Biosci, Unesp Botucatu, SP - Brazil

^[2] UNESP Univ State Sao Paulo, Dept Anat, Inst Biosci, Unesp Botucatu, SP - Brazil

^[3] UNICAMP Univ Campinas, Inst Biol, Dept Anat Cellular Biol Physiol & Biophys, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Food and Chemical Toxicology; v. 50, n. 10, p. 3556-3561, OCT 2012.
• Citações Web of Science: 34

Resumo

We reported the effects of quercetin on metabolic and hormonal profile as well as serum antioxidant activities in a model of MSG (monosodium glutamate)-induced obesity. Rats were divided into 4 groups: MSG group, submitted to neonatal treatment with high doses of MSG, administrated subcutaneously during 10 days, from 2 day-old; control groups, which received the same volume of saline. After completing 30 day-old, these groups were subdivided into 4 groups: control and MSG groups treated and non-treated with quercetin at doses of 75 mg/kg body weight (i.p.) over 42 days. BW gain and food consumption were higher in MSG treated rats and quercetin significantly reduced BW by 25%. While MSG increased triacylglycerol, total cholesterol and fractions, and reduced HDL concentrations, administration of quercetin normalized HDL-cholesterol and reduced others lipids. Insulin, leptin, glucose and creatinine levels were raised in MSG-treated rats and reduced after quercetin treatment. Alanine transaminase, aspartate transaminase, lactate dehydrogenase and alkaline phosphatase activities were lower after MSG-quercetin combination compared to rats given only MSG. MSG-quercetin combination augmented total protein and urea levels as well as glutathione peroxidase and superoxide dismutase activities in contrast to MSG-treated animals. Quercetin normalized serum lipid and glucose profile and minimized the MSG-related toxic effects, which was associated to its antioxidant properties. (C) 2012 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 02/03359-5 - Efeito da quercetina sobre aspectos bioquimicos em ratos tratados com glutamato monossodico.
• Beneficiário: Ana Angélica Henrique Fernandes
• Modalidade de apoio: Auxílio à Pesquisa - Regular