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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations

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Author(s):
Seiva, Fabio R. F. [1] ; Chuffa, Luiz Gustavo A. [2] ; Braga, Camila Pereira [1] ; Amorim, Joao Paulo A. [3] ; Fernandes, Ana Angelica H. [1]
Total Authors: 5
Affiliation:
[1] UNESP Univ State Sao Paulo, Dept Chem & Biochem, Inst Biosci, Unesp Botucatu, SP - Brazil
[2] UNESP Univ State Sao Paulo, Dept Anat, Inst Biosci, Unesp Botucatu, SP - Brazil
[3] UNICAMP Univ Campinas, Inst Biol, Dept Anat Cellular Biol Physiol & Biophys, Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Food and Chemical Toxicology; v. 50, n. 10, p. 3556-3561, OCT 2012.
Web of Science Citations: 34
Abstract

We reported the effects of quercetin on metabolic and hormonal profile as well as serum antioxidant activities in a model of MSG (monosodium glutamate)-induced obesity. Rats were divided into 4 groups: MSG group, submitted to neonatal treatment with high doses of MSG, administrated subcutaneously during 10 days, from 2 day-old; control groups, which received the same volume of saline. After completing 30 day-old, these groups were subdivided into 4 groups: control and MSG groups treated and non-treated with quercetin at doses of 75 mg/kg body weight (i.p.) over 42 days. BW gain and food consumption were higher in MSG treated rats and quercetin significantly reduced BW by 25%. While MSG increased triacylglycerol, total cholesterol and fractions, and reduced HDL concentrations, administration of quercetin normalized HDL-cholesterol and reduced others lipids. Insulin, leptin, glucose and creatinine levels were raised in MSG-treated rats and reduced after quercetin treatment. Alanine transaminase, aspartate transaminase, lactate dehydrogenase and alkaline phosphatase activities were lower after MSG-quercetin combination compared to rats given only MSG. MSG-quercetin combination augmented total protein and urea levels as well as glutathione peroxidase and superoxide dismutase activities in contrast to MSG-treated animals. Quercetin normalized serum lipid and glucose profile and minimized the MSG-related toxic effects, which was associated to its antioxidant properties. (C) 2012 Elsevier Ltd. All rights reserved. (AU)