Supplementation with leucine and quercetin, possible role on adipose tissue and skeletal muscle metabolism. In vivo and in vitro study.

• Grant number: 13/12366-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2014
• End date: April 30, 2017
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Lila Missae Oyama
• Grantee: Mayara Franzoi Moreno
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated scholarship(s): 14/22439-7 - Quercetin and leucine effects on the gut microbiota, intestinal permeability, and metabolic endotoxemia in HIGH-FAT-FED mice, BE.EP.DR

Abstract

Adipose tissue is an endocrine organ involved in the pathogenesis of metabolic disorders present in obesity, which produces cytokines and adipokines, which trigger a series of adaptive mechanisms to obesity. Similar to adipose tissue, skeletal muscle also produce substances involved in the regulation of metabolic processes, and it has been suggested an interrelationship between all these tissues in regulating metabolism. On the other hand, given the problems related to obesity, pharmacological or nutritional supplementation intervention approaches have become increasingly attractive, in a population where a sedentary lifestyle and poor eating habits are prevalent. Much has been studied about the bioactive compounds of quercetin, which has antioxidant, anti-inflammatory, ability to improve lipid metabolism and reduce atherosclerotic lesion. As with leucine studies have shown beneficial effects on peripheral glucose, lipid metabolism, and suggest its use in treating metabolic disorders. Reviewing the literature, we found that leucine and quercetin are widely studied individually. However, we don't found scientific studies on the synergistic benefits of the administration of the same till date. We believe that co-administration of leucine and quercetin in vivo and in vitro presented benefits because of the additive and synergistic effect of the two compounds. The aims of this project is investigate whether there was an association between the consumption of leucine and quercetin on the expression of inflammatory mediators and metabolism in adipose tissue, skeletal muscle of animals fed high-fat diets, which could elucidate the role this amino acid and this flavonoid as potential therapeutic agents.