Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Down-regulation of ANAPC13 and CLTCL1: Early Events in the Progression of Preinvasive Ductal Carcinoma of the Breast

Texto completo
Autor(es):
Mostrar menos -
Sens-Abuazar, Carolina [1] ; Napolitano e Ferreira, Elisa [1] ; Bueno Toledo Osorio, Cynthia Aparecida [2] ; Victorino Krepischi, Ana Cristina [3, 4] ; Ricca, Tatiana Iervolino [1] ; Castro, Nadia Pereira [1] ; da Cunha, Isabela Werneck [2] ; Maciel, Maria do Socorro [5] ; Rosenberg, Carla [6, 3] ; Brentani, Maria Mitzi [7] ; Soares, Fernando Augusto [2] ; Rocha, Rafael Malagoli [2] ; Carraro, Dirce Maria [1, 3]
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] AC Camargo Hosp, Int Ctr Res & Teaching, Lab Genom & Mol Biol, BR-01508010 Sao Paulo - Brazil
[2] AC Camargo Hosp, Int Ctr Res & Teaching, Dept Investigat Pathol, BR-01508010 Sao Paulo - Brazil
[3] Natl Inst Sci & Technol Oncogen, Sao Paulo - Brazil
[4] AC Camargo Hosp, Int Ctr Res & Teaching, Canc Genet Lab, BR-01508010 Sao Paulo - Brazil
[5] AC Camargo Hosp, Dept Mastol, BR-01508010 Sao Paulo - Brazil
[6] Univ Sao Paulo, Inst Biosci, Dept Genet & Evolutionary Biol, Sao Paulo - Brazil
[7] Univ Sao Paulo, Sch Med, Dept Radiol, Discipline Oncol, Sao Paulo - Brazil
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: TRANSLATIONAL ONCOLOGY; v. 5, n. 2, p. 113-U105, APR 2012.
Citações Web of Science: 7
Resumo

Alterations in the gene expression profile in epithelial cells during breast ductal carcinoma (DC) progression have been shown to occur mainly between pure ductal carcinoma in situ (DCIS) to the in situ component of a lesion with coexisting invasive ductal carcinoma (DCIS-IDC) implying that the molecular program for invasion is already established in the preinvasive lesion. For assessing early molecular alterations in epithelial cells that trigger tumorigenesis and testing them as prognostic markers for breast ductal carcinoma progression, we analyzed, by reverse transcription-quantitative polymerase chain reaction, eight genes previously identified as differentially expressed between epithelial tumor cells populations captured from preinvasive lesions with distinct malignant potential, pure DCIS and the in situ component of DCIS-IDC. ANAPC13 and CLTCL1 down-regulation revealed to be early events of DC progression that anticipated the invasiveness manifestation. Further down-regulation of ANAPC13 also occurred after invasion appearance and the presence of the protein in invasive tumor samples was associated with higher rates of overall and disease-free survival in breast cancer patients. Furthermore, tumors with low levels of ANAPC13 displayed increased copy number alterations, with significant gains at 1q (1q23.1-1q32.1), 8q, and 17q (17q24.2), regions that display common imbalances in breast tumors, suggesting that down-regulation of ANAPC13 contributes to genomic instability in this disease. (AU)

Processo FAPESP: 09/02457-2 - Avaliação do papel das variantes de splicing dos genes TRIM37, BRRN1 e MK-STYX na gênese e progressão do câncer de mama
Beneficiário:Tatiana Iervolino Ricca
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 09/00669-2 - Identificação e validação de marcadores moleculares para risco de progressão de carcinoma ductal de mama
Beneficiário:Carolina Sens Abuázar
Linha de fomento: Bolsas no Brasil - Doutorado