Oxindoles and copper complexes with oxindole-derivatives as potential pharmacological agents

Autor(es)

Giselle Cerchiaro ^[1] ; Ana Maria da Costa Ferreira ^[2]

Afiliação do(s) autor(es)

^[1] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil

^[2] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 17, n. 8, p. 1473-1485, 2006-12-00.

Resumo

Oxindoles are endogenous compounds found in mammalian body fluids and tissues. Particularly, isatin (1H-indole-2,3-dione) and its derivatives have shown a variety of biological effects, including inhibition of monoamine oxidase, antibacterial, antifungal, antiviral and antiproliferative activities. Recent reports have described these compounds as efficient inhibitors of kinases, a class of proteins involved in many steps of the cellular cycle. Here, some copper(II) complexes with oxindole-derived ligands are discussed as potential antitumoral agents, in comparison to other complexes, based on the proposal of a synergistic effect on adding the metal coordinating and redox properties to the already demonstrated capability of these ligands to influence the angiogenesis and apoptosis processes. (AU)

• Processo FAPESP: 01/09127-6 - Estudos inorganicos de especies metalicas com potencial aplicacao em catalise, farmacologica e bioinorganica.
• Beneficiário: Ana Maria da Costa Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Regular