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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Oxindoles and copper complexes with oxindole-derivatives as potential pharmacological agents

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Author(s):
Giselle Cerchiaro [1] ; Ana Maria da Costa Ferreira [2]
Total Authors: 2
Affiliation:
[1] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil
[2] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil
Total Affiliations: 2
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 17, n. 8, p. 1473-1485, 2006-12-00.
Abstract

Oxindoles are endogenous compounds found in mammalian body fluids and tissues. Particularly, isatin (1H-indole-2,3-dione) and its derivatives have shown a variety of biological effects, including inhibition of monoamine oxidase, antibacterial, antifungal, antiviral and antiproliferative activities. Recent reports have described these compounds as efficient inhibitors of kinases, a class of proteins involved in many steps of the cellular cycle. Here, some copper(II) complexes with oxindole-derived ligands are discussed as potential antitumoral agents, in comparison to other complexes, based on the proposal of a synergistic effect on adding the metal coordinating and redox properties to the already demonstrated capability of these ligands to influence the angiogenesis and apoptosis processes. (AU)