| Texto completo | |
| Autor(es): Mostrar menos - |
de Souza, Lucas R.
[1]
;
Melo, Pollyana M.
[2]
;
Paschoalin, Thaysa
[2]
;
Carmona, Adriana K.
[2]
;
Kondo, Marcia
[2]
;
Hirata, Izaura Y.
[2]
;
Blaber, Michael
[3]
;
Tersariol, Ivarne
[4]
;
Takatsuka, Joyce
[5]
;
Juliano, Maria A.
[2]
;
Juliano, Luiz
[2]
;
Gomes, Roseli A.
[5]
;
Puzer, Luciano
[1]
Número total de Autores: 13
|
| Afiliação do(s) autor(es): | [1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Santo Andre, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Biofis, Sao Carlos, SP - Brazil
[3] Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 - USA
[4] Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo - Brazil
[5] Univ Fed Triangulo Mineiro, Inst Ciencias Biol & Nat, Uberaba, MG - Brazil
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Biochemical and Biophysical Research Communications; v. 433, n. 3, p. 333-337, APR 12 2013. |
| Citações Web of Science: | 6 |
| Resumo | |
Human tissue kallikreins (KLKs) are a group of serine proteases found in many tissues and biological fluids and are differentially expressed in several specific pathologies. Here, we present evidences of the ability of these enzymes to activate plasminogen. Kallikreins 3 and 5 were able to induce plasmin activity after hydrolyzing plasminogen, and we also verified that plasminogen activation was potentiated in the presence of glycosaminoglycans compared with plasminogen activation by tPA. This finding can shed new light on the plasminogen/plasmin system and its involvement in tumor metastasis, in which kallikreins appear to be upregulated. (C) 2013 Elsevier Inc. All rights reserved. (AU) | |
| Processo FAPESP: | 11/51297-8 - Desenvolvimento de inibidores para as calicreínas teciduais humanas 5 e 7 (KLK5 e KLK7) |
| Beneficiário: | Luciano Puzer |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |