| Full text | |
| Author(s): Show less - |
de Souza, Lucas R.
[1]
;
Melo, Pollyana M.
[2]
;
Paschoalin, Thaysa
[2]
;
Carmona, Adriana K.
[2]
;
Kondo, Marcia
[2]
;
Hirata, Izaura Y.
[2]
;
Blaber, Michael
[3]
;
Tersariol, Ivarne
[4]
;
Takatsuka, Joyce
[5]
;
Juliano, Maria A.
[2]
;
Juliano, Luiz
[2]
;
Gomes, Roseli A.
[5]
;
Puzer, Luciano
[1]
Total Authors: 13
|
| Affiliation: | [1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Santo Andre, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Biofis, Sao Carlos, SP - Brazil
[3] Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 - USA
[4] Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo - Brazil
[5] Univ Fed Triangulo Mineiro, Inst Ciencias Biol & Nat, Uberaba, MG - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Biochemical and Biophysical Research Communications; v. 433, n. 3, p. 333-337, APR 12 2013. |
| Web of Science Citations: | 6 |
| Abstract | |
Human tissue kallikreins (KLKs) are a group of serine proteases found in many tissues and biological fluids and are differentially expressed in several specific pathologies. Here, we present evidences of the ability of these enzymes to activate plasminogen. Kallikreins 3 and 5 were able to induce plasmin activity after hydrolyzing plasminogen, and we also verified that plasminogen activation was potentiated in the presence of glycosaminoglycans compared with plasminogen activation by tPA. This finding can shed new light on the plasminogen/plasmin system and its involvement in tumor metastasis, in which kallikreins appear to be upregulated. (C) 2013 Elsevier Inc. All rights reserved. (AU) | |
| FAPESP's process: | 11/51297-8 - Development of inhibitors for human tissue kallikreins 5 and 7 (KLK5 and KLK7) |
| Grantee: | Luciano Puzer |
| Support Opportunities: | Regular Research Grants |