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Impact of HPV infection on the development of head and neck cancer

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Autor(es):
Betiol, J. [1] ; Villa, L. L. [2, 1, 3] ; Sichero, L. [1]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Inst Canc Estado Sao Paulo, Ctr Invest Translac Oncol, Lab Biol Mol, BR-01246000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, Dept Radiol & Oncol, Sao Paulo - Brazil
[3] Santa Casa de Misericordia Sao Paulo, Inst HPV, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Brazilian Journal of Medical and Biological Research; v. 46, n. 3, p. 217-226, Mar. 2013.
Citações Web of Science: 18
Resumo

Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is considered to be a distinct clinical entity with better prognosis than the classical tobacco- and alcohol-associated tumors. The increasing incidence of this neoplasia during the last decades highlights the need to better understand the role of HPV in the development of these cancers. Although the proportion of HNSCC attributed to HPV varies considerably according to anatomical site, overall approximately 25% of all HNSCC are HPV-DNA positive, and HPV-16 is by far the most prevalent type. In this review we discuss the existing evidence for a causal association between HPV infection and HNSCC at diverse anatomical head and neck subsites. (AU)