Impact of HPV infection on the development of head and neck cancer

Autor(es)

J. Betiol ^[1] ; L.L. Villa ^{[2, 1, 3]} ; L. Sichero ^[1]

Afiliação do(s) autor(es)

^[1] Inst Canc Estado Sao Paulo, Ctr Invest Translac Oncol, Lab Biol Mol, BR-01246000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med, Dept Radiol & Oncol, Sao Paulo - Brazil

^[3] Santa Casa de Misericordia Sao Paulo, Inst HPV, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 46, n. 3, p. 217-226, 2013-03-15.

Resumo

Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is considered to be a distinct clinical entity with better prognosis than the classical tobacco- and alcohol-associated tumors. The increasing incidence of this neoplasia during the last decades highlights the need to better understand the role of HPV in the development of these cancers. Although the proportion of HNSCC attributed to HPV varies considerably according to anatomical site, overall approximately 25% of all HNSCC are HPV-DNA positive, and HPV-16 is by far the most prevalent type. In this review we discuss the existing evidence for a causal association between HPV infection and HNSCC at diverse anatomical head and neck subsites. (AU)

• Processo FAPESP: 12/01513-9 - Diversidade de HPV e Risco de Câncer
• Beneficiário: Julio Cesar Betiol
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 11/09616-9 - Diversidade de HPV e risco de câncer
• Beneficiário: Luisa Lina Villa
• Modalidade de apoio: Auxílio à Pesquisa - Regular