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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Paper-filtered coffee increases cholesterol and inflammation biomarkers independent of roasting degree: A clinical trial

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Autor(es):
Correa, Telma A. F. [1] ; Rogero, Marcelo M. [1] ; Mioto, Bruno M. [2] ; Tarasoutchi, Daniela [2] ; Tuda, Vera L. [2] ; Cesar, Luiz A. M. [2] ; Torres, Elizabeth A. F. S. [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: NUTRITION; v. 29, n. 7-8, p. 977-981, JUL-AUG 2013.
Citações Web of Science: 24
Resumo

Objective: The aim of this study was to compare the effects of medium light roast (MLR) and medium roast (MR) paper-filtered coffee on cardiovascular risk factors in healthy volunteers. Methods: This randomized crossover trial compared the effects of consuming three or four cups (150 mL) of MLR or MR coffee per day for 4 wk in 20 healthy volunteers. Plasma lipids, lipoprotein(a) (Lp{[}a]), total homocysteine, and endothelial dysfunction-related inflammation biomarkers, serum glycemic biomarkers, and blood pressure were measured at baseline and after each intervention. Results: Both roasts increased plasma total cholesterol, low-density lipoprotein-cholesterol, and soluble vascular cell adhesion molecule-1 (sVCAM-1) concentrations (10%, 12%, and 18% for MLR; 12%, 14%, and 14% for MR, respectively) (P < 0.05). MR also increased high-density lipoportein-cholesterol concentration by 7% (P = 0.003). Plasma fibrinogen concentration increased 8% after MR intake (P = 0.01), and soluble E-selectin increased 12% after MLR intake (P = 0.02). No changes were observed for Lp(a), total homocysteine, glycemic biomarkers, and blood pressure. Conclusion: Moderate paper-filtered coffee consumption may have an undesirable effect on plasma cholesterol and inflammation biomarkers in healthy individuals regardless of its antioxidant content. (C) 2013 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 08/10933-6 - Estudo da ação antioxidante e dos efeitos dos compostos bioativos do café na prevenção de doenças crônicas não transmissíveis: dislipidemia, diabetes mellitus tipo 2 e hipertensão arterial
Beneficiário:Telma Angelina Faraldo Corrêa
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 09/05792-7 - Estudo da ação antioxidante e dos efeitos dos compostos bioativos do café sobre o metabolismo glico-lipídico e pressão arterial
Beneficiário:Elizabeth Aparecida Ferraz da Silva Torres
Linha de fomento: Auxílio à Pesquisa - Regular