Paper-filtered coffee increases cholesterol and inflammation biomarkers independent of roasting degree: A clinical trial

Autor(es)

Correa, Telma A. F. ^[1] ; Rogero, Marcelo M. ^[1] ; Mioto, Bruno M. ^[2] ; Tarasoutchi, Daniela ^[2] ; Tuda, Vera L. ^[2] ; Cesar, Luiz A. M. ^[2] ; Torres, Elizabeth A. F. S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION; v. 29, n. 7-8, p. 977-981, JUL-AUG 2013.
• Citações Web of Science: 24

Resumo

Objective: The aim of this study was to compare the effects of medium light roast (MLR) and medium roast (MR) paper-filtered coffee on cardiovascular risk factors in healthy volunteers. Methods: This randomized crossover trial compared the effects of consuming three or four cups (150 mL) of MLR or MR coffee per day for 4 wk in 20 healthy volunteers. Plasma lipids, lipoprotein(a) (Lp{[}a]), total homocysteine, and endothelial dysfunction-related inflammation biomarkers, serum glycemic biomarkers, and blood pressure were measured at baseline and after each intervention. Results: Both roasts increased plasma total cholesterol, low-density lipoprotein-cholesterol, and soluble vascular cell adhesion molecule-1 (sVCAM-1) concentrations (10%, 12%, and 18% for MLR; 12%, 14%, and 14% for MR, respectively) (P < 0.05). MR also increased high-density lipoportein-cholesterol concentration by 7% (P = 0.003). Plasma fibrinogen concentration increased 8% after MR intake (P = 0.01), and soluble E-selectin increased 12% after MLR intake (P = 0.02). No changes were observed for Lp(a), total homocysteine, glycemic biomarkers, and blood pressure. Conclusion: Moderate paper-filtered coffee consumption may have an undesirable effect on plasma cholesterol and inflammation biomarkers in healthy individuals regardless of its antioxidant content. (C) 2013 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 08/10933-6 - Estudo da ação antioxidante e dos efeitos dos compostos bioativos do café na prevenção de doenças crônicas não transmissíveis: dislipidemia, diabetes mellitus tipo 2 e hipertensão arterial
• Beneficiário: Telma Angelina Faraldo Corrêa
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 09/05792-7 - Estudo da ação antioxidante e dos efeitos dos compostos bioativos do café sobre o metabolismo glico-lipídico e pressão arterial
• Beneficiário: Elizabeth Aparecida Ferraz da Silva Torres
• Modalidade de apoio: Auxílio à Pesquisa - Regular