Paper-filtered coffee increases cholesterol and inflammation biomarkers independent of roasting degree: A clinical trial

Author(s)

Correa, Telma A. F. ^[1] ; Rogero, Marcelo M. ^[1] ; Mioto, Bruno M. ^[2] ; Tarasoutchi, Daniela ^[2] ; Tuda, Vera L. ^[2] ; Cesar, Luiz A. M. ^[2] ; Torres, Elizabeth A. F. S. ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo - Brazil

• Document type: Journal article
• Source: NUTRITION; v. 29, n. 7-8, p. 977-981, JUL-AUG 2013.
• Web of Science Citations: 24

Abstract

Objective: The aim of this study was to compare the effects of medium light roast (MLR) and medium roast (MR) paper-filtered coffee on cardiovascular risk factors in healthy volunteers. Methods: This randomized crossover trial compared the effects of consuming three or four cups (150 mL) of MLR or MR coffee per day for 4 wk in 20 healthy volunteers. Plasma lipids, lipoprotein(a) (Lp{[}a]), total homocysteine, and endothelial dysfunction-related inflammation biomarkers, serum glycemic biomarkers, and blood pressure were measured at baseline and after each intervention. Results: Both roasts increased plasma total cholesterol, low-density lipoprotein-cholesterol, and soluble vascular cell adhesion molecule-1 (sVCAM-1) concentrations (10%, 12%, and 18% for MLR; 12%, 14%, and 14% for MR, respectively) (P < 0.05). MR also increased high-density lipoportein-cholesterol concentration by 7% (P = 0.003). Plasma fibrinogen concentration increased 8% after MR intake (P = 0.01), and soluble E-selectin increased 12% after MLR intake (P = 0.02). No changes were observed for Lp(a), total homocysteine, glycemic biomarkers, and blood pressure. Conclusion: Moderate paper-filtered coffee consumption may have an undesirable effect on plasma cholesterol and inflammation biomarkers in healthy individuals regardless of its antioxidant content. (C) 2013 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 08/10933-6 - STUDY OF ANTIOXIDANT ACTION AND THE BIOACTIVE COMPOUNDS EFFECTS OF COFFEE IN THE PREVENTION OF CHRONIC DISEASES NOT TRANSMISSIBLE: DYSLIPIDEMIA, DIABETES MELLITUS TYPE 2 AND ARTERIAL HYPERTENSION
• Grantee: Telma Angelina Faraldo Corrêa
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 09/05792-7 - Study of antioxidant action and the bioactive compounds effects of coffee in the metabolism glico-lipidic and arterial hypertension
• Grantee: Elizabeth Aparecida Ferraz da Silva Torres
• Support Opportunities: Regular Research Grants