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Study of antioxidant action and the bioactive compounds effects of coffee in the metabolism glico-lipidic and arterial hypertension

Abstract

Coffee is rich in bioactive substances and it is among the major contributors to the antioxidants ingestion in several countries. Roasting grade of grains and the method of brewing are extremely important for its antioxidant action. Studies indicate that the moderate consumption of this beverage is involved in the prevention of chronic diseases not transmissible, which are usually associated, constitute serious problems of Public Health and they are cause of premature deaths in adults. However, literature presents no consensus about the beneficial effects of coffee in prevention of these diseases and its components involved in these effects. This study aims at verifying the effect of the ingestion of regular filtered coffee (light and dark roasting) on biomarkers of the oxidative stress and inflammatory response in healthy human after 4 and 8 weeks, and quantify the components associated with this purpose Decaffeinated and/or espresso coffees may be used too. Twenty healthy individuals, between 20 and 65 years old, will be selected after answer a questionnaire and make tests which will show their health: physical, nutritional, laboratory (hematocrit, hemoglobin, glycated hemoglobin (HbA1), total cholesterol and fractions and fasting glycemia and others). Data will be analyzed by Statistica software, version 7. The paired test t of Fisher will be applied. ANOVA will be used in case of more than one moment (before coffee ingestion, after four weeks and after the coffee ingestion - 8 weeks), for comparisons intra-group. Categorical variables will be analyzed by chi-square. The non paired test t of Fisher will be applied for comparisons between groups. Tukey test will be used for comparisons of more than one group of analysis. In the case of variables that do not have a normal distribution, the tests of Wilcoxon, for the two groups, and the Kruskal-Wallis, for more than two groups of comparison, shall be realized. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FARALDO CORREA, TELMA ANGELINA; MONTEIRO, MARCELA PIEDADE; NOGUEIRA MENDES, THAISE MARIA; DE OLIVEIRA, DANIELA MOURA; ROGERO, MARCELO MACEDO; BENITES, CIBELEM IRIBARREM; CHRISTIANO DE MATOS VINAGRE, CARMEN GUILHERME; MIOTO, BRUNO MAHLER; TARASOUTCHI, DANIELA; TUDA, VERA LUCIA; et al. Medium Light and Medium Roast Paper-Filtered Coffee Increased Antioxidant Capacity in Healthy Volunteers: Results of a Randomized Trial. PLANT FOODS FOR HUMAN NUTRITION, v. 67, n. 3, p. 277-282, . (08/10933-6, 09/05792-7)
CORREA, TELMA A. F.; ROGERO, MARCELO M.; MIOTO, BRUNO M.; TARASOUTCHI, DANIELA; TUDA, VERA L.; CESAR, LUIZ A. M.; TORRES, ELIZABETH A. F. S.. Paper-filtered coffee increases cholesterol and inflammation biomarkers independent of roasting degree: A clinical trial. NUTRITION, v. 29, n. 7-8, p. 977-981, . (08/10933-6, 09/05792-7)

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