Diabetic Rats Exercised Prior to and During Pregnancy: Maternal Reproductive Outcome, Biochemical Profile, and Frequency of Fetal Anomalies

Autor(es)

Damasceno, Debora Cristina ^[1] ; Silva, Hellen Pontes ^[1] ; Vaz, Geizi Fatima ^[1] ; Vasques-Silva, Francine Aparecida ^[1] ; Paranhos Calderon, Iracema Mattos ^[1] ; Cunha Rudge, Marilza Vieira ^[1] ; Campos, Kleber Eduardo ^{[1, 2]} ; Volpato, Gustavo Tadeu ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista Unesp, Botucatu Med Sch, Lab Expt Res Gynecol & Obstet, Botucatu, SP - Brazil

^[2] Mato Grosso Fed Univ UFMT, Univ Ctr Araguaia, Inst Biol & Hlth Sci, Lab Gen Physiol & Reprod Toxicol, Barra Do Garcas, Mato Grosso - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: REPRODUCTIVE SCIENCES; v. 20, n. 7, p. 730-738, JUL 2013.
• Citações Web of Science: 20

Resumo

The aim of this study was to evaluate the effects of exercise prior to or during pregnancy on maternal reproductive outcome, biochemical profile, and on fetal anomaly frequency in a rat pregnancy model utilizing chemically induced diabetes. Wistar rats (minimum n = 11 animals/group) were randomly assigned the following groups: group 1 (G1), sedentary, nondiabetic; G2, nondiabetic, exercised during pregnancy; G3, nondiabetic, exercised prior to and during pregnancy; G4, sedentary, diabetic; G5, diabetic, exercised during pregnancy; and G6, diabetic, exercised prior to and during pregnancy. A swimming program was utilized for moderate exercise. On day 21 of pregnancy, all rats were anesthetized to obtain blood for biochemical measurements. The gravid uterus was weighed with its contents, and the fetuses were analyzed. The nondiabetic rats exercised prior to pregnancy presented a reduced maternal weight gain. Besides, G2 and G3 groups showed decreased fetal weights at term pregnancy, indicating slight intrauterine growth restriction (IUGR). In the diabetic dams, the swimming program did not have antihyperglycemic effects. The exercise applied only during pregnancy caused severe IUGR, as confirmed by reduced fetal weight mean, fetal weight classification, and ossification sites. Nevertheless, exercise was not a teratogenic factor and improved the rats' lipid profiles, demonstrating that the exercise presented possible benefits, but there are also risks prior and during pregnancy, especially in diabetic pregnant women. (AU)

• Processo FAPESP: 06/57202-0 - Efeito isolado do exercicio fisico, iniciado em diferentes momentos, sobre a perfomance reprodutiva de ratas nao-diabeticas e diabeticas.
• Beneficiário: Héllen Pontes da Silva
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 05/02386-7 - Efeito isolado do exercício físico iniciado em diferentes momentos na prenhez de ratas diabéticas e não diabéticas
• Beneficiário: Débora Cristina Damasceno
• Modalidade de apoio: Auxílio à Pesquisa - Regular