Role of brain nitric oxide in the cardiovascular control of bullfrogs

Autor(es)

Zena, Lucas A. ; Gargaglioni, Luciane H. ; Bicego, Kenia C. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, Coll Agr & Vet Sci, Dept Anim Morphol & Physiol, BR-14884900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY; v. 165, n. 2, p. 263-271, JUN 2013.
• Citações Web of Science: 4

Resumo

The goal of the present study was to determine if nitric oxide (NO) acting on the brain of bullfrog (Lithobates catesbeianus) is involved in arterial pressure and heart rate (HR) control by influencing sympathetic activity. We investigated the effect of intracerebroventricular injections of L-NMMA (a nonselective NO synthase inhibitor) on mean arterial blood pressure (MAP), HR and cutaneous vascular conductance (CVC) of pelvic skin after intravenous injection of alpha or beta adrenergic blockers, prazosin or sotalol, respectively. Arterial pressure was directly measured by a telemetry sensor inserted in the aortic arch of animals. L-NMMA increased MAP, but did not change HR. This hypertensive response was inhibited by the pre-treatment with prazosin, but accentuated by sotalol. The effect of L-NMMA on MAP was also inhibited by i.v. injections of the ganglionic blocker, hexamethonium. Thus, NO acting on the brain of bullfrog seems to present a hypotensive effect influencing the sympathetic activity dependent on alpha and beta adrenergic receptors in the periphery. (C) 2013 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 08/57712-4 - Instituto Nacional de Pesquisas em Fisiologia Comparada
• Beneficiário: Augusto Shinya Abe
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 10/04368-4 - Participação do óxido nítrico encefálico no controle cardiovascular de rãs
• Beneficiário: Lucas Aparecido Zena
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 10/08765-8 - Participação do óxido nítrico encefálico no controle cardiovascular em rãs
• Beneficiário: Kênia Cardoso Bícego
• Modalidade de apoio: Auxílio à Pesquisa - Regular