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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Role of brain nitric oxide in the cardiovascular control of bullfrogs

Full text
Author(s):
Zena, Lucas A. ; Gargaglioni, Luciane H. ; Bicego, Kenia C. [1]
Total Authors: 3
Affiliation:
[1] Sao Paulo State Univ, Coll Agr & Vet Sci, Dept Anim Morphol & Physiol, BR-14884900 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY; v. 165, n. 2, p. 263-271, JUN 2013.
Web of Science Citations: 4
Abstract

The goal of the present study was to determine if nitric oxide (NO) acting on the brain of bullfrog (Lithobates catesbeianus) is involved in arterial pressure and heart rate (HR) control by influencing sympathetic activity. We investigated the effect of intracerebroventricular injections of L-NMMA (a nonselective NO synthase inhibitor) on mean arterial blood pressure (MAP), HR and cutaneous vascular conductance (CVC) of pelvic skin after intravenous injection of alpha or beta adrenergic blockers, prazosin or sotalol, respectively. Arterial pressure was directly measured by a telemetry sensor inserted in the aortic arch of animals. L-NMMA increased MAP, but did not change HR. This hypertensive response was inhibited by the pre-treatment with prazosin, but accentuated by sotalol. The effect of L-NMMA on MAP was also inhibited by i.v. injections of the ganglionic blocker, hexamethonium. Thus, NO acting on the brain of bullfrog seems to present a hypotensive effect influencing the sympathetic activity dependent on alpha and beta adrenergic receptors in the periphery. (C) 2013 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 08/57712-4 - The National Institute of Comparative Physiological Research
Grantee:Augusto Shinya Abe
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 10/04368-4 - Role of encefalic nitric oxide in cardiovascular control of frogs
Grantee:Lucas Aparecido Zena
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 10/08765-8 - Role of brain nitric oxide in the cardiovascular control of frogs
Grantee:Kênia Cardoso Bícego
Support Opportunities: Regular Research Grants