Correlation between Beta1 integrin expression and prognosis in clinically localized prostate cancer

Autor(es)

Pontes-Junior, Jose ^{[1, 2]} ; Reis, Sabrina Thalita ^[2] ; Bernardes, Felipe S. ^[2] ; Oliveira, Luiz C. N. ^{[1, 2]} ; Felix de Barros, Erika Aparecida ^[1] ; Dall'Oglio, Marcos Francisco ^[2] ; Timosczuk, Luciana M. S. ^[2] ; Ribeiro-Filho, Leopoldo A. ^[2] ; Srougi, Miguel ^[2] ; Leite, Katia R. M. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Nove Julho, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Dept Urol, Lab Med Invest LIM 55, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL BRAZ J UROL; v. 39, n. 3, p. 335-342, MAY-JUN 2013.
• Citações Web of Science: 6

Resumo

Integrins are transmembrane glycoprotein receptors that regulate cell-matrix interactions, thus functioning as sensors from the environment. They also act as cell adhesion molecules that are responsible for the maintenance of the normal epithelial phenotype. Some studies have reported a correlation between carcinogenesis and changes in integrin expression, especially beta 1 integrin, however its role in prostate cancer (PC) is unclear. The aim of our study was to evaluate the expression of beta 1 integrin in localized PC and to correlate the pattern of expression with recurrence after surgical treatment. Methods For this case-control study, we retrospectively selected surgical specimens from 111 patients with localized PC who underwent radical prostatectomy. Recurrence was defined as a PSA level exceeding 0.2ng/mL after surgery, and the median follow-up was 123 months. Integrin expression was evaluated by immunohistochemistry in a tissue microarray containing two samples from each tumor. We employed a semiquantitative analysis and considered a case as positive when the expression was strong and diffusely present. Results: There was a loss of 11 cases during the tissue micro array assembling. beta 1 expression was positive in 79 of the 100 evaluated cases (79%). The univariate and multivariate analyses showed that the negative expression of beta 1 integrin was associated with biochemical recurrence (p = 0.047) and time to recurrence after radical prostatectomy (p = 0.023). When beta 1 was negative, the odds ratio for recurrence was 2.78 times higher than that observed in the positive cases {[}OR = 2.78, p = 0.047, IC 95% (1.01-7.66)]. Conclusions: The loss of beta 1 integrin immune expression was correlated with biochemical recurrence in patients treated with radical prostatectomy for localized PC. (AU)

• Processo FAPESP: 10/19525-8 - Análise e implicação prognóstica da expressão de moléculas de adesão no adenocarcinoma de próstata localizado
• Beneficiário: Felipe Saraiva Bernardes
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica