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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Influence of Acute Sleep Deprivation on Cardiovascular Parameters in Female Zucker Obese and Lean Rats

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Autor(es):
Tenorio, Neuli M. [1] ; Tufik, Sergio [1] ; Bergamaschi, Cassia T. [2] ; Campos, Ruy R. [2] ; Cintra, Fatima [1] ; Alvarenga, Tathiana A. [1] ; Andersen, Monica L. [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo UNIFESP, Dept Psicobiol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Fisiol, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: OBESITY; v. 21, n. 3, p. 510-515, MAR 2013.
Citações Web of Science: 1
Resumo

Objective: There is a reciprocal relationship between sleep duration and weight gain. However, the consequences of this relationship on the cardiovascular system over an entire life span are still not fully elucidated. We examined the effect of acute sleep deprivation (SD) on baroreflex sensitivity and blood pressure in Zucker rats of different ages. Design and Methods: Female lean and obese Zucker rats at 3, 6 and 15 months of age were assigned to SD or control (CTRL) groups. After a 6 h period of the SD procedure (6 h of gentle handling) or CTRL procedure (an equivalent period without handling), the animals were anesthetized for surgical catheterization of the femoral artery and vein. To evaluate the baroreflex sensitivity index, bolus infusions of phenylephrine (bradycardia response) and sodium nitroprusside (tachycardia response) were administered. Results: Obesity resulted in dysfunctional tachycardia responses at 3 months of age. At 6 and 15 months of age, both bradycardia and tachycardia responses were significantly lower in obese animals than those in lean animals. At 15 months of age, interactions among obesity, SD and aging produced the most marked effects on the cardiovascular system (increased mean arterial pressure and heart rate and decreased baroreflex sensitivity). Conclusions: Therefore, these results suggest that there is no direct relationship between baroreflex imbalance and an increase in arterial pressure. (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs