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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of Acute Sleep Deprivation on Cardiovascular Parameters in Female Zucker Obese and Lean Rats

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Author(s):
Tenorio, Neuli M. [1] ; Tufik, Sergio [1] ; Bergamaschi, Cassia T. [2] ; Campos, Ruy R. [2] ; Cintra, Fatima [1] ; Alvarenga, Tathiana A. [1] ; Andersen, Monica L. [1]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Paulo UNIFESP, Dept Psicobiol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Fisiol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: OBESITY; v. 21, n. 3, p. 510-515, MAR 2013.
Web of Science Citations: 1
Abstract

Objective: There is a reciprocal relationship between sleep duration and weight gain. However, the consequences of this relationship on the cardiovascular system over an entire life span are still not fully elucidated. We examined the effect of acute sleep deprivation (SD) on baroreflex sensitivity and blood pressure in Zucker rats of different ages. Design and Methods: Female lean and obese Zucker rats at 3, 6 and 15 months of age were assigned to SD or control (CTRL) groups. After a 6 h period of the SD procedure (6 h of gentle handling) or CTRL procedure (an equivalent period without handling), the animals were anesthetized for surgical catheterization of the femoral artery and vein. To evaluate the baroreflex sensitivity index, bolus infusions of phenylephrine (bradycardia response) and sodium nitroprusside (tachycardia response) were administered. Results: Obesity resulted in dysfunctional tachycardia responses at 3 months of age. At 6 and 15 months of age, both bradycardia and tachycardia responses were significantly lower in obese animals than those in lean animals. At 15 months of age, interactions among obesity, SD and aging produced the most marked effects on the cardiovascular system (increased mean arterial pressure and heart rate and decreased baroreflex sensitivity). Conclusions: Therefore, these results suggest that there is no direct relationship between baroreflex imbalance and an increase in arterial pressure. (AU)

FAPESP's process: 98/14303-3 - Center for Sleep Studies
Grantee:Sergio Tufik
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC