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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Angiotensin converting enzyme insertion/deletion polymorphism is associated with increased adiposity and blood pressure in obese children and adolescents

Texto completo
Autor(es):
Lemes, Vinicius A. F. [1] ; Neves, Ana Luisa [2, 3] ; Guazzelli, Isabel C. [1] ; Frazzatto, Eliana [1] ; Nicolau, Christiane [1] ; Correa-Giannella, Maria Lucia [1] ; Velho, Gilberto [2] ; Villares, Sandra M. F. [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sao Paulo FMUSP, Fac Med, Lab Endocrinol Celular & Mol LIM25, Sao Paulo - Brazil
[2] INSERM, Res Unit 695, Paris - France
[3] Univ Porto, Fac Med, P-4100 Oporto - Portugal
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Gene; v. 532, n. 2, p. 197-202, DEC 15 2013.
Citações Web of Science: 12
Resumo

Background: The insertion/deletion polymorphism in the gene encoding the angiotensin-converting enzyme (ACE I/D) was associated with arterial hypertension and obesity in adults, but the data in children are scarce and yielded contrasting results. We assessed the impact of the ACE I/D on blood pressure and obesity related traits in a Brazilian cohort of obese children and adolescents. Methods and results: ACE I/D was genotyped in 320 obese children and adolescents (64% of girls) aged 7-16 years, referred for a weight-loss program. We observed an association of the D-allele with blood pressure and with pre-hypertension/hypertension in boys (odds ratio 2.44,95% C.I. 1.34-4.68, p = 0.005 for a codominant model). The D-allele, insulin resistance and body fat mass had independent and additive effects and explained 14% of the variance of pre-hypertension/hypertension. The BMI, waist circumference, and body fat mass were significantly higher in DD/ID boys than in II boys (p < 0.005). Allelic associations with obesity related traits were independent of the association with blood pressure. No genotype associations were observed in girls. Conclusions: The D-allele of the ACE I/D polymorphism was associated with arterial hypertension and with obesity related traits in boys, but not in girls, in a cohort of obese children and adolescents. These associations were independent of each other, as well as of the effects of other confounding traits such as insulin secretion, insulin sensitivity and glucose tolerance. Our results are in agreement with experimental evidences suggesting that the renin-angiotensin system plays a role in the regulation of visceral adipose tissue accumulation. (C) 2013 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 05/53730-0 - Avaliação de mutações e polimorfismos do gene da adiponectina em crianças e adolescentes obesos
Beneficiário:Christiane Yumi Muramoto Nicolau
Linha de fomento: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 09/00337-0 - Impacto do polimorfismo da Enzima Conversora de Angiotensina I (ACE) nos parâmetros antropométricos e na sensibilidade à insulina em crianças e adolescentes obesas e a resposta ao tratamento multidisciplinar de mudança do estilo de vida
Beneficiário:Vinicius Augusto Ferreira Lemes
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 04/14272-3 - Avaliação de mutações e polimorfismos do gene de adiponectina em crianças e adolescentes obesos
Beneficiário:Sandra Mara Ferreira Villares
Linha de fomento: Auxílio à Pesquisa - Regular