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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Angiotensin converting enzyme insertion/deletion polymorphism is associated with increased adiposity and blood pressure in obese children and adolescents

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Author(s):
Lemes, Vinicius A. F. [1] ; Neves, Ana Luisa [2, 3] ; Guazzelli, Isabel C. [1] ; Frazzatto, Eliana [1] ; Nicolau, Christiane [1] ; Correa-Giannella, Maria Lucia [1] ; Velho, Gilberto [2] ; Villares, Sandra M. F. [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo FMUSP, Fac Med, Lab Endocrinol Celular & Mol LIM25, Sao Paulo - Brazil
[2] INSERM, Res Unit 695, Paris - France
[3] Univ Porto, Fac Med, P-4100 Oporto - Portugal
Total Affiliations: 3
Document type: Journal article
Source: Gene; v. 532, n. 2, p. 197-202, DEC 15 2013.
Web of Science Citations: 12
Abstract

Background: The insertion/deletion polymorphism in the gene encoding the angiotensin-converting enzyme (ACE I/D) was associated with arterial hypertension and obesity in adults, but the data in children are scarce and yielded contrasting results. We assessed the impact of the ACE I/D on blood pressure and obesity related traits in a Brazilian cohort of obese children and adolescents. Methods and results: ACE I/D was genotyped in 320 obese children and adolescents (64% of girls) aged 7-16 years, referred for a weight-loss program. We observed an association of the D-allele with blood pressure and with pre-hypertension/hypertension in boys (odds ratio 2.44,95% C.I. 1.34-4.68, p = 0.005 for a codominant model). The D-allele, insulin resistance and body fat mass had independent and additive effects and explained 14% of the variance of pre-hypertension/hypertension. The BMI, waist circumference, and body fat mass were significantly higher in DD/ID boys than in II boys (p < 0.005). Allelic associations with obesity related traits were independent of the association with blood pressure. No genotype associations were observed in girls. Conclusions: The D-allele of the ACE I/D polymorphism was associated with arterial hypertension and with obesity related traits in boys, but not in girls, in a cohort of obese children and adolescents. These associations were independent of each other, as well as of the effects of other confounding traits such as insulin secretion, insulin sensitivity and glucose tolerance. Our results are in agreement with experimental evidences suggesting that the renin-angiotensin system plays a role in the regulation of visceral adipose tissue accumulation. (C) 2013 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 09/00337-0 - Impact of angiotensin converting enzyme i (ACE)POLYMORPHISM in anthropometric measures and in insulin sensivity in obese children and teenagers, and their response to a multidisciplinary treatment of life style change
Grantee:Vinicius Augusto Ferreira Lemes
Support type: Scholarships in Brazil - Scientific Initiation