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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Supervised physical exercise improves endothelial function in patients with systemic lupus erythematosus

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Autor(es):
dos Reis-Neto, Edgard Torres [1] ; da Silva, Aline Evelyn [1] ; de Castro Monteiro, Carlos Manoel [2] ; de Camargo, Luciano Monteiro [2] ; Sato, Emilia Inoue [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Div Rheumatol, Escola Paulista Med UNIFESP EPM, BR-04023900 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Div Cardiol, Escola Paulista Med UNIFESP EPM, BR-04023900 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: RHEUMATOLOGY; v. 52, n. 12, p. 2187-2195, DEC 2013.
Citações Web of Science: 18
Resumo

Objective. The objective of this study was to evaluate the effect of supervised physical exercise on endothelial function, ergospirometric test variables and disease activity in SLE patients. Methods. We conducted a prospective study in which women with SLE who were available to perform physical exercise were allocated to the exercise group (EG) to practise supervised physical exercise for 1 h three times per week for 16 weeks. Those who were not available for this activity were allocated to the control group (CG). Intervention consisted of walking at a heart rate corresponding to the ventilatory 1 threshold obtained from ergospirometry and monitored by a frequency meter. At baseline (T0) and after 16 weeks (T16), patients were assessed for endothelial function by brachial artery (flow-mediated dilation), ergospirometry and disease activity (SLEDAI). Statistical analysis was performed through normality tests, Student's t-test and non-parametric tests for data with non-normal distribution. P < 0.05 was considered significant. Results. Eighteen patients were allocated in the EG and 20 in the CG. After 16 weeks there was an increase in FMD in the EG {[}6.3 (6.7)% vs 14.1 (9.1)%, P = 0.006] without a change in the CG {[}8.4 (8.2)% vs 9.4 (5.7)%, P = 0.598]. Regarding the ergospirometric test, we found improvement in exercise tolerance {[}12.3 (2.4) vs 13.4 (2.6) min, P = 0.027], maximum speed {[}7.7 (1.0) vs 8.3 (1.2) km/h, P = 0.027] and threshold speed {[}5.6 (0.7) vs 6.1 (0.9) km/h, P = 0.005] in the EG without a difference in the CG. There was no difference in the SLEDAI score in both groups. Conclusion. Physical exercise is a useful strategy to improve endothelial function and aerobic capacity without worsening disease activity in SLE patients. (AU)

Processo FAPESP: 08/07350-9 - Efeito do exercício físico supervisionado sobre a função endotelial de pacientes com lupus eritematoso sistêmico
Beneficiário:Edgard Torres dos Reis Neto
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 08/09295-5 - Efeito do exercício físico supervisionado sobre a função endotelial e células progenitoras endoteliais em pacientes com lúpus eritematoso sistêmico
Beneficiário:Emilia Inoue Sato
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 10/09743-8 - Efeito do exercício físico supervisionado sobre a função endotelial e células progenitoras endoteliais em pacientes com Lúpus Eritematoso Sistêmico
Beneficiário:Edgard Torres dos Reis Neto
Linha de fomento: Bolsas no Brasil - Doutorado Direto