Production of the First Effective Hyperimmune Equine Serum Antivenom against Africanized Bees

Autor(es):Mostrar menos -

Santos, Keity Souza ^{[1, 2, 3]} ; Stephano, Marco Antonio ^[4] ; Marcelino, Jose Roberto ^[5] ; Resende Ferreira, Virginia Maria ^{[1, 2]} ; Rocha, Thalita ^[6] ; Caricati, Celso ^[7] ; Higashi, Hisako Gondo ^[8] ; Moro, Ana Maria ^{[1, 9]} ; Kalil, Jorge Elias ^{[1, 2, 3]} ; Malaspina, Osmar ^{[1, 10]} ; Morato Castro, Fabio Fernandes ^{[1, 2, 3]} ; Palma, Mario Sergio ^{[1, 10]}

Afiliação do(s) autor(es)

^[1] Inst Invest Immunol INCT, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, FMUSP, Div Clin Immunol & Allergy, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Heart Inst InCor, LIM 19, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Fac Ciencias Farmaceut, Sao Paulo - Brazil

^[5] Butantan Inst, Div Hyperimmune Plasmas, Sao Paulo - Brazil

^[6] Univ Sao Francisco, Sch Med, BR-12900000 Braganca Paulista, SP - Brazil

^[7] Butantan Inst, Special Pilot Lab Res & Dev Vet Immunobiol, Sao Paulo - Brazil

^[8] Inst Technol Parana, Curitiba, Parana - Brazil

^[9] Butantan Inst, Lab Biopharmaceut Anim Cells, Sao Paulo - Brazil

^[10] Univ Sao Paulo State UNESP, Ctr Study Social Insects, Inst Biosci, Dept Biol, Rio Claro, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 8, n. 11 NOV 13 2013.
• Citações Web of Science: 5

Resumo

Victims of massive bee attacks become extremely ill, presenting symptoms ranging from dizziness and headache to acute renal failure and multiple organ failure that can lead to death. Previous attempts to develop specific antivenom to treat these victims have been unsuccessful. We herein report a F(ab)'(2)-based antivenom raised in horse as a potential new treatment for victims of multiple bee stings. The final product contains high specific IgG titers and is effective in neutralizing toxic effects, such as hemolysis, cytotoxicity and myotoxicity. The assessment of neutralization was revised and hemolysis, the primary toxic effect of these stings, was fully neutralized in vivo for the first time. (AU)

• Processo FAPESP: 11/51684-1 - Biologia de sistemas como estratégia experimental para a descoberta de novos produtos naturais na fauna de artrópodes peçonhentos do Estado de São Paulo
• Beneficiário: Mario Sergio Palma
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático