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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Modeling interleukin-2-based immunotherapy in AIDS pathogenesis

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Autor(es):
Joly, Marcel [1, 2] ; Odloak, Darci [1]
Número total de Autores: 2
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Proc Control & Simulat Lab, BR-05508900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Publ Hlth, BR-01246904 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Journal of Theoretical Biology; v. 335, p. 57-78, OCT 21 2013.
Citações Web of Science: 6
Resumo

In this paper, we sought to identify the CD4(+) T-cell dynamics in the course of HIV infection in response to continuous and intermittent intravenous courses of interleukin-2 (IL-2), the principal cytokine responsible for progression of CD4(+) T-lymphocytes from the Cl to the S phase of the cell cycle. Based on multivariate regression models, previous literature has concluded that the increase in survival of CD4(+) T-cell appears to be the critical mechanism leading to sustained CD4(+) T-cell levels in HIV-infected patients receiving intermittent IL-2 therapy. Underscored by comprehensive mathematical modeling, a major finding of the present work is related to the fact that, rather than due to any increase in survival of CD4(+) T-cells, the expressive, selective and sustained CD4(+) T-cell expansions following IL-2 administration may be related to the role of IL-2 in modulating the dynamics of Fas-dependent apoptotic pathways, such as activation-induced cell death (AICD) or HIV-specific apoptotic routes triggered by viral proteins. (C) 2013 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 99/09897-4 - Metodologias para a operação de Scheduling ótimos de sistemas reativos em batelada
Beneficiário:Marcel Joly
Linha de fomento: Bolsas no Brasil - Doutorado